Results 91 to 100 of about 34,044 (268)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Educational and guidance values of 4-H clubs
, 1932 The purpose of this study is to analyze the activities of the 4-H Clubs in order to discover; first, their educational values and second, their guidance values. One of the most discussed topics of the day is Federal Aid for agriculture.
Jones, Jason W.
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
The technology clubs: the distribution of knowledge across nations
The convergence clubs literature in applied growth theory suggests that countries that differ in terms of structural characteristics and initial conditions tend to experience diverging growth performances.
Castellacci, Fulvio
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4-H Leadership Development in Southern Maine: Community Clubs vs. School/Afterschool Clubs
, 2015 In Maine and across the United States, the 4-H Youth Development Program places great importance on youth’s self-discovery, experiential learning, and development of leadership skills. Founded in 1902, the 4-H program was created through A.B.
Personette, Laura, MA
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Approximate cores of games and economies with clubs [PDF]
, 2001 We introduce the framework of parameterized collections of games and provide three nonemptiness of approximate core theorems for arbitrary games with and without sidepayments.
Wooders, Myrna Holtz +1 more
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Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
What factors contribute to older youth retention in 4-H? [PDF]
, 2008 Includes bibliographical ...
Nutt, Bonnie L.
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