Results 91 to 100 of about 3,179,234 (258)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Florida 4-H Cloverbud Project Report
EDIS, 2023 The 4-H Cloverbud Project Summary is intended for youth ages 5–7 to complete at the completion of a 4-H educational project. This 7-page revision was compiled by the Florida 4-H Awards and Recognition Task Force; Geralyn Sachs and Laura Cash, chairs.
Laura Cash +7 more
openaire +2 more sources
Business Environment Institutions in the Light of the Operational Programme Innovative Economy (OP IE) [PDF]
, 2013 Realizacja jednego z siedmiu projektów przewodnich wskazanych w „Strategii Europa 2020 – Polityka przemysłowa w erze globalizacji” nakłada na instytucje otoczenia biznesu obowiązek świadczenia usług na rzecz MŚP na najwyższym poziomie.
Fabińska, Monika
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Florida 4-H Intermediate Project Report
EDIS, 2023 This report form is to be completed by intermediate (age 11–13) 4-H members as a record of their 4-H project completion. Project Reports should be turned in annually at the end of the 4-H year to their county 4-H agent. This 10-page major revision was compiled by the Florida 4-H Awards and Recognition Task Force; Geralyn Sachs and Laura Cash, chairs ...
Laura Cash +7 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Evaluating Random Mutant Selection at Class-Level in Projects with Non-Adequate Test Suites
, 2016 Mutation testing is a standard technique to evaluate the quality of a test suite. Due to its computationally intensive nature, many approaches have been proposed to make this technique feasible in real case scenarios.
Demeyer, Serge +2 more
core +1 more source