Results 171 to 180 of about 411,931 (223)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Hypoxia-activated PROTAC for dual inhibition of FAK and EGFR enables synergistic mechano-chemical cancer therapy. [PDF]

Neoplasia
An K, Li Y, Cao C, Wang M, Jia X, Jin G, Cheng B, Jia Y, Wang L, Guo H, Xu F, Qu K.   +11 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A taxonomy for detecting and preventing temporal data leakage in machine learning-based build prediction: A dual-platform empirical validation. [PDF]

PLoS One
Mishra LN, Rangari A, Nagrare S, Nayak SK.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Structural Characterization of Chondroitin Sulfate from Hybrid Sturgeon (<i>Acipenser schrenckii</i> × <i>Huso dauricus</i>) Cartilage and Its Alleviating Effect on Osteoarthritis. [PDF]

Nutrients
Zhang S, Li Y, Yu M, Zhao X, Liu Z, Yang T, Wang C, Hou H.   +7 more
europepmc   +1 more source

STEAP2-associated modulation of PI3K/AKT/mTOR signaling contributes to ginkgetin-induced apoptosis in bladder cancer cells. [PDF]

Hereditas
Wu P, Chen L, Yang J, Liang Z, Yin X, Zhou S, Deng Z, Yang Y.   +7 more
europepmc   +1 more source

Patient and public involvement in health and social care doctoral research: recommendations co-produced by doctoral researchers, public contributors, and a public involvement coordinator. [PDF]

Res Involv Engagem
Curry J, Bowers SP, Wray A, Fearfull A, Roberts H.   +4 more
europepmc   +1 more source

A comprehensive framework for evaluating bridge project rework through earned value management (EVM) and building information modeling (BIM). [PDF]

Sci Rep
Elseufy SM, Hussein A, Badawy M.
europepmc   +1 more source