Results 181 to 190 of about 3,179,234 (258)

The network pharmacology prediction and experiment validation of Astragalus membranaceus for alleviating silicosis fibrosis via decreasing MMP9 and EGFR expression. [PDF]

Sci Rep
Yang A, Luo X, Guo Y, Zhang H, Zhang W, Chang S, Wen S, Yang W, Sun Y.   +8 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Scaling what works: a collaborative capacity-building program tailored to optimize resources and scale evidence-based interventions for cancer prevention and control. [PDF]

Cancer Causes Control
Wangen M, Xu J, Tran A, Rohan EA, Adsul P, Escoffery C, Ferrari RM, Hayes N, Herington C, Jones K, King JH, Kranick J, LaMonica A, Lee RJ, O'Leary MC, Pereira M, Puckett M, Ricardo S, Robles-Morales R, Smith K, Spees LP, Thompson A, Wheeler SB, Woodard N, Brenner AT, Hirschey R.   +25 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Insight into the genetic diversity of Hyalomma scupense, Ixodes persulcatus, Haemaphysalis punctata and Argas persicus in Kazakhstan. [PDF]

Exp Appl Acarol
Awulibieer M, Toksanbaevich ZK, Maidanniyati D, Rysbayuli SA, Serik K, Hornok S, Yang M, Zhenisbekkyzy KA, Wang Y, Hazihan W.   +9 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Implementation status and quality improvement strategies of the record-filing system for drug clinical trial institutions in Sichuan Province. [PDF]

Front Med (Lausanne)
Qin S, Zhou H.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC): An infrastructure for accelerating regenerative therapies from discovery to clinical impact. [PDF]

J Clin Transl Sci
Nguyen VX, Yoshida M, Samuels BD, Giannobile W, Healy KE, Jamieson M, Lane N, Longaker MT, Mooney DJ, Sfeir CS, Sinha UK, Wagner WR, Lotz JC, Kohn DH, Chai Y.   +14 more
europepmc   +1 more source