Results 1 to 10 of about 7,822 (231)

4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development [PDF]

Frontiers in Immunology, 2023
4-Nitroquinoline N-oxide (4-NQO) and its derivatives react with genomic DNA to form stable quinolone monoadducts, which are highly mutagenic and genotoxic.
Satya Ranjan Sahu, Satya Ranjan Sahu, Shweta Thakur, Doureradjou Peroumal, Bhabasha Gyanadeep Utkalaja, Bhabasha Gyanadeep Utkalaja, Abinash Dutta, Premlata Kumari, Premlata Kumari, Ipsita Subhadarsini, Ipsita Subhadarsini, Narottam Acharya   +11 more
doaj   +4 more sources

Food-Associated Lactobacillus plantarum and Yeasts Inhibit the Genotoxic Effect of 4-Nitroquinoline-1-Oxide [PDF]

Frontiers in Microbiology, 2017
Lactic acid bacteria and yeasts, representing the prevailing microbiota associated with different foods generally consumed without any cooking, were identified and characterized in vitro for some functional properties, such as acid-bile tolerance and ...
Roberta Prete, Rosanna Tofalo, Ermanno Federici, Aurora Ciarrocchi, Giovanni Cenci, Aldo Corsetti   +5 more
doaj   +4 more sources

Effect of exposure to the carcinogen 50 ppm 4-nitroquinoline 1-oxide on alveolar bone loss

Journal of Indian Society of Periodontology
Background: The objective of this study was to analyze the effect of exposure to the carcinogen 4-nitroquinoline 1-oxide (4NQO), with or without experimental periodontitis (EP), on alveolar bone loss (ABL) in rats. Materials and Methods: Male Wistar rats
Marcelo Ekman Ribas, Tobias Rauber Spuldaro, Harry Juan Rivera Oballe, Juliano Cavagni, Eduardo José Gaio, Marcelo Lazzaron Lamers, Francisco Wilker Mustafa Gomes Muniz, Cassiano Kuchenbecker Rösing   +7 more
doaj   +3 more sources

4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment [PDF]

Frontiers in Oncology
Oral tongue squamous cell carcinoma (OTSCC) is the most common cancer of the oral cavity and is associated with high morbidity due to local invasion and lymph node metastasis.
Kjersti Sellæg, Ruth Schwienbacher, Ruth Schwienbacher, Mathias Kranz, Anna Engan Aamodt, Anna M. Wirsing, Gerd Berge, Elin Hadler-Olsen, Elin Hadler-Olsen, Synnøve Norvoll Magnussen   +9 more
doaj   +4 more sources

Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. [PDF]

Carcinogenesis, 2011
Dietary zinc (Zn) deficiency is implicated in the pathogenesis of human oral-esophageal cancers. In rats, Zn deficiency causes increased cell proliferation and cyclooxygenase-2 (COX-2) overexpression and enhances oral carcinogenesis by 4-nitroquinoline 1-oxide (NQO). Zn replenishment reverses all these effects.
Fong LY, Jiang Y, Rawahneh ML, Smalley KJ, Croce CM, Farber JL, Huebner K.   +6 more
europepmc   +5 more sources

Fat and exposure to 4-nitroquinoline-1-oxide causes histologic and inflammatory changes in murine livers. [PDF]

PLoS ONE, 2022
Risk factors for liver cancer include tobacco use, alcohol consumption, obesity, and male sex. Administration of 4-nitroquinonline-1-oxide (4NQO) in drinking water mimics the effects of tobacco and leads to oral carcinoma in mice. This study compared the
Lenore D Pitstick, Joanna Goral, Ryan A Schmelter, Christine M Fuja, Mae J Ciancio, Matthew Pytynia, Alice Meyer, Jacalyn M Green   +7 more
doaj   +3 more sources

Polyclonal Antibodies to DNA Modified with 4‐Nitroquinoline 1‐Oxide: Application for the Detection of 4‐Nitroquinoline 1‐Oxide‐DNA Adducts in vivo [PDF]

Japanese Journal of Cancer Research, 1988
Antibodies against 4‐nitroquinoline 1‐oxide (4NQO) adducts were elicited in rabbits immunized with 4NQO‐modified DNA complexed with methylated bovine serum albumin. In enzymelinked immunosorbent assay (ELISA), the antibodies could recognize either denatured or native 4NQO‐modified DNA, but not unmodified DNA, DNA modified with other carcinogens or free
Toshiteru Morita, Sachiya Ikeda, Yasushi Minoura, Misaki Kojima, Mariko Tada   +4 more
openalex   +3 more sources

Areca nut extract increased stromal tumor-infiltrating lymphocytes in 4-nitroquinoline-1-oxide-tumor-induced Sprague-Dawley rats [version 4; peer review: 1 approved, 2 approved with reservations] [PDF]

F1000Research, 2022
Background Oral squamous cell carcinoma (OSCC) is one of the most common oral cancers with a high mortality rate. The biodiversity source in Indonesia makes areca nut a potential antioxidant in treating disease.
Dina Keumala Sari, Cut Fera Novita, Poppy Andriany, Liza Meutia Sari   +3 more
doaj   +2 more sources

Correction to: Alleviation of 4-nitroquinoline 1-oxide induced oxidative stress by Oroxylum indicum (L.) leaf extract in albino Wistar rats [PDF]

BMC Complementary Medicine and Therapies, 2022
An amendment to this paper has been published and can be accessed via the original article.
Shalini Mohan, Kalaivani Thiagarajan, Balaji Sundaramoorthy, Vivek Gurung, Manas Barpande, Shilpi Agrawal, Rajasekaran Chandrasekaran   +6 more
doaj   +2 more sources

Reduction of 4-Nitroquinoline 1-Oxide by Microörganisms

Chemical and Pharmaceutical Bulletin, 1962
The ultraviolet absorption maximum of 4-nitroquinoline 1-oxide was shifted toward shorter wave length when the substance was added to the growing media of microorganisms. The investigation of this phenomenon revealed that the shift in ultraviolet absorption maxima is due to the reduction of nitro group at 4-position. It was also foundthat the reduction
Tadashi Okabayashi, Akihiro Yoshimoto
openalex   +3 more sources