Results 91 to 100 of about 7,822 (231)

STIP1 drives Metabolic Reprogramming in Esophageal Squamous Cell Carcinoma via AHCY‐LDHA Axis

Exploration, Volume 5, Issue 5, October 2025.
A schematic model illustrating that LCA can inhibit ESCC growth by inhibiting the STIP1/AHCY/LDHA axis. In brief. Jin et al. demonstrated that targeting STIP1 can significantly inhibit the progression of esophageal squamous cell carcinoma. The high expression of STIP1 increased the interaction between AHCY and LDHA and then AHCY recruits PRMT3 to ...
Guoguo Jin, Yanming Song, Mingyang Yan, Shaobo Fang, Yang Shao, Kexin Zhao, Meng Liu, Qinxin Guo, Xinyang Jia, Chengjuan Zhang, Zhenwei Wang, Kangdong Liu, Xiang Li, Simin Zhao, Mee‐Hyun Lee, Zhiping Guo, Zigang Dong   +16 more
wiley   +1 more source

Estimates of DNA damage by the comet assay in the direct-developing frog Eleutherodactylus johnstonei (Anura, Eleutherodactylidae)

Genetics and Molecular Biology, 2011
The aim of this study was to use the Comet assay to assess genetic damage in the direct-developing frog Eleutherodactylus johnstonei. A DNA diffusion assay was used to evaluate the effectiveness of alkaline, enzymatic and alkaline/enzymatic treatments ...
Laura Carolina Valencia, Adriana García, Martha Patricia Ramírez-Pinilla, Jorge Luis Fuentes   +3 more
doaj  

Evaluation of Quercus infectoria Phytoconstituents Against Oral Cancer: Network Pharmacology, Docking Simulation, and In Vitro Cytotoxicity Assay

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
This study illustrates a workflow exploring Quercus infectoria against oral cancer through network pharmacology, target prediction, molecular docking, DFT, molecular dynamics, and pathway enrichment. Molecular docking showed strong binding affinities of Nyctanthic acid and β‐Glucogallin with AKT1 and GAPDH, respectively, with the Nyctanthic acid‐AKT1 ...
Priyanka Kamaria, Priyanka Tiwari, Prabitha Prabhakaran, Sakshi Bhardwaj, Krishna Kolachi, Shankar Thapa   +5 more
wiley   +1 more source

Reply to the opinion paper “The impact of stress on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide: some theoretical concepts for scientific debate” by Silva et al. [PDF]

, 2022
Giseli Mitsuy Kayahara, Flávia Alves Verza, Vítor Bonetti Valente, Glauco Issamu Miyahara, Daniel Galera Bernabé   +4 more
openalex   +1 more source

Evaluating the Genotoxicity and Mutagenicity of Food Contaminants: Acrylamide, Penitrem A, and 3‐Acetyldeoxynivalenol in Individual and Combined Exposure In Vitro

Journal of Applied Toxicology, Volume 45, Issue 9, Page 1750-1760, September 2025.
ABSTRACT This study aimed to evaluate the genotoxic effects of food contaminants exposure in human neuroblastoma SH‐SY5Y cells using the micronucleus (MN) assay and Ames test. Acrylamide (AA), penitrem A (PEN A), and 3‐acetyldeoxynivalenol (3‐ADON) were tested both individually and in combination.
Luna Bridgeman, Cristina Juan, Houda Berrada, Isabelle Severin, Ana Juan‐García   +4 more
wiley   +1 more source

Chemical fate and genotoxic risk associated with hypochlorite treatment of nicotine [PDF]

, 2012
Nicotine, the main alkaloid of tobacco, is a non-prescription drug to which all members of a tobacco-smoking society are exposed either through direct smoke inhalation or through second-hand passive 'smoking'.
Cermola F., Della Greca M., Iesce M.R., Isidori M., Lavorgna M., Parolisi A., Passananti M., Previtera L., Temussi F., Zarrelli A.   +9 more
core   +1 more source

Responses of entomopathogenic fungi to the mutagen 4-nitroquinoline 1-oxide

Fungal Biology, 2018
Survival of entomopathogenic fungi under solar ultraviolet (UV) radiation is paramount to the success of biological control of insect pests and disease vectors. The mutagenic compound 4-nitroquinoline 1-oxide (4-NQO) is often used to mimic the biological effects of UV radiation on organisms.
Claudinéia A.S. Araújo, Luciana P. Dias, Paulo C. Ferreira, Josane Mittmann, Breno Pupin, Guilherme.T.P. Brancini, Gilberto Ú.L. Braga, Drauzio E.N. Rangel   +7 more
openaire   +3 more sources

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites

Environmental and Molecular Mutagenesis, Volume 66, Issue 6-7, Page 327-340, August 2025.
ABSTRACT We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub‐regions of the gene to be more or less prone to mutations when compared with other sub‐regions.
Katherine Douglas, Dana Sorensen, Arnav Saud, Ananya Sridharan, Mallika Mathew, Jyotsna Hiranandani, Ava Gonick, Courtney Young, Kelly Nguyen, Nhu Phi, Jeffrey H. Miller   +10 more
wiley   +1 more source

All-trans retinoic acid restores gap junctional intercellular communication between oral cancer cells with upregulation of Cx32 and Cx43 expressions in vitro [PDF]

, 2013
Objective: All-trans retinoic acid (ATRA) has been demonstrated to inhibit tumor growth by restoration of gap junctional intercellular communication (GJIC) via upregulation of connexin (Cx) expression in some solid tumors.
Chen, Xiaohua, Cheng, Bin, Dai, Yaohui, Hong, Yun, Huang, Yulei, Wang, Hong, Wang, Juan, Xia, Yu-Juan   +7 more
core   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, Volume 45, Issue 8, Page 1614-1636, August 2025.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source