Sex-Related Differences in Histone Acetylation and Tumor Development in a 4-Nitroquinoline 1-Oxide and Ethanol-Induced Oral Squamous Cell Carcinoma Mouse Model. [PDF]
J Oral Pathol MedABSTRACT Background Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4‐nitroquinoline 1‐oxide (4NQO) mouse model of oral carcinogenesis is a well‐established model to investigate the mechanism behind OSCC development, including epigenetic alterations.
Nazário WR +9 more
europepmc +4 more sources
Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism [PDF]
Frontiers in Microbiology, 2018 Microbiota has been widely considered to play a critical role in human carcinogenesis. Human papilloma virus, hepatitis B and C virus, and Helicobacter pylori are implicated in the pathogenesis of cancer of uterine cervix, liver, and stomach ...
Jia-shun Wu +10 more
doaj +2 more sources
Use of 4-Nitroquinoline 1-Oxide (4NQO) in Dysplastic and Malignant Induction: In Vitro and In Vivo Studies [PDF]
BiomedicinesObjectives: Tobacco has been associated with the development of oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC). This study aimed to evaluate the in vitro and in vivo changes caused by carcinogen 4-nitroquinoline 1-oxide (4NQO), simulating ...
Daniela Oliveira Meneses +9 more
doaj +2 more sources
Impact of Juglone, a PIN1 İnhibitor, on Oral Carcinogenesis Induced by 4-Nitroquinoline-1-Oxide (4NQO) in Rat Model [PDF]
MedicinaBackground and Objectives: PIN1 is overexpressed in several human cancers, including prostate cancer, breast cancer, and oral squamous carcinomas. Juglone (J), derived from walnut, was reported to selectively inhibit PIN1 by modifying its sulfhydryl ...
Olgun Topal +7 more
doaj +2 more sources
Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing. [PDF]
G3 (Bethesda), 2014 4-Nitroquinoline 1-oxide (4-NQO) is a highly carcinogenic chemical that induces mutations in bacteria, fungi, and animals through the formation of bulky purine adducts.
Downes DJ +5 more
europepmc +6 more sources
Therapeutic Efficacy of Orally Delivered Doxorubicin Nanoparticles in Rat Tongue Cancer Induced by 4-Nitroquinoline 1-Oxide [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell carcinoma makes up about 94% of oral malignancies.
Monir Moradzadeh Khiavi +8 more
doaj +2 more sources
Cytoprotective effects of (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) against 4-nitroquinoline 1-oxide-induced damage in CCD-18Co human colon fibroblast cells. [PDF]
PLoS ONE, 2020 Stilbenes are a group of chemicals characterized with the presence of 1,2-diphenylethylene. Previously, our group has demonstrated that synthesized (E)-N-(2-(3, 5-dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) possesses potential chemopreventive ...
Huan Huan Tan +3 more
doaj +2 more sources
A method for scoring 4-nitroquinoline 1-oxide-induced murine esophageal squamous neoplasia. [PDF]
Vet Pathol, 2023 Aziz Z +3 more
europepmc +2 more sources
4-nitroquinoline-1-oxide-induced mutagen sensitivity and risk of cutaneous melanoma: a case-control analysis. [PDF]
Melanoma Res, 2016 Wang LE +9 more
europepmc +2 more sources