Results 201 to 210 of about 7,822 (231)

Interactions of 4-nitroquinoline 1-oxide with deoxyribodinucleotides

Biochemistry, 1979
The interactions of 4-nitroquinoline 1-oxide (NQO), a potent mutagen and carcinogen, with several self- and non-self-complementary deoxydinucleotides were probed by using absorption spectra of the charge transfer bands and 1H and 13C NMR spectra. Absorption spectra were analyzed by using Benesi-Hildebrand-type equations to yield stoichiometries and ...
S A, Winkle, I, Tinoco
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Mutagenicity of 4-nitroquinoline 1-oxide in the Muta™Mouse

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1999
As part of a collaborative study, the Mammalian Mutagenesis Study Group (MMS), a sub-organization of the Environmental Mutagen Society of Japan (JEMS) conducted mutagenicity tests in MutaMouse. Using a positive selection method, we studied the organ-specificity and time dependence of mutation induction by 4-nitroquinoline 1-oxide (4NQO).
M, Nakajima, M, Kikuchi, K, Saeki, Y, Miyata, M, Terada, F, Kishida, R, Yamamoto, C, Furihata, S W, Dean   +8 more
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4-Nitroquinoline-1-Oxide: Factors determining its mutagenicity in bacteria

Mutation Research/Genetic Toxicology, 1981
In bacteria, 4-nitroquinoline-1-oxide (NQO) causes primarily mutations of the base-substitution type although frameshift mutations are also induced. The adducts formed are presumably recognized by error-prone DNA repair enzymes as evidenced by the much greater activity in plasmid pKM101-bearing tester strains.
E C, McCoy, L A, Petrullo, H S, Rosenkranz, R, Mermelstein   +3 more
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Toxicity of 4‐Nitroquinoline 1‐Oxide for Crithidia fasciculata

The Journal of Protozoology, 1975
SYNOPSISGrowth inhibition of Crithidia fasciculata by 4‐nitroquinoline 1‐oxide (NQO) was observed in defined and complex media at 28 C. Aromatic amino acids, cysteine, and nicotinic acid, among several other substances, were ineffective in overcoming NQO toxicity. Dicoumarol and bovine albumin reversed NQO inhibition.
W, Leon, F S, Cruz, M E, Vasconcellos
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4 Nitroquinoline 1‐oxide‐induced carcinogenesis in the rat palate

Journal of Oral Pathology & Medicine, 1983
Most reported studies of experimental oral cancer have been carried out in the hamster. This animal is not available in certain countries and there is controversy regarding its suitability as a model for experimental oral carcinogenesis. An attempt was made to reproduce an experimental oral cancer model in rats, using a protocol based on that described
P N, Wong, D F, Wilson
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Molecular Biology of the Carcinogen, 4-Nitroquinoline 1-Oxide

1976
Publisher Summary Studies on chemical carcinogenesis have three main purposes. First is to elucidate carcinogenic mechanisms, second is to prevent possible carcinogenic hazard due to chemicals in the environment, and third is to provide clinical model systems in experimental animals. Recent studies on chemical carcinogens and mutagens have shown that,
M, Nagao, T, Sugimura
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Caffeine inhibits cell transformation by 4-nitroquinoline-1-oxide

Nature, 1975
SOMATIC mutation has been considered a likely initiating step in chemical carcinogenesis1–3, chiefly because of the close correlation between the mutagenic and carcinogenic activity of various chemicals4–6. Study of cells from patients with disease predisposing to a high incidence of cancer, such as xeroderma pigmentosum and Fanconi's anaemia, has ...
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4-nitroquinoline-1-oxide (4NQO) induced oral carcinogenesis: A systematic literature review

Pathology - Research and Practice, 2022
Based on a critical review of published studies, we aimed to develop a good practice guide for using 4-nitroquinoline-1-oxide (4NQO) as an inducer of oral carcinogenesis in Wistar rats.A systematic search was performed on Medline Ovid, PubMed, Embase, Web of Science, and Scopus databases. The SYRCLE's risk of bias tool was used to assess the quality of
Gisele Corrêa de Oliveira, Zigmundo, Lauren Frenzel, Schuch, Tuany Rafaeli, Schmidt, Felipe Martins, Silveira, Marco Antônio Trevizani, Martins, Vinicius Coelho, Carrard, Manoela Domingues, Martins, Vivian Petersen, Wagner   +7 more
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Reactions of 4-Nitroquinoline 1-Oxide with Aluminum Chloride

Russian Journal of Organic Chemistry, 2001
4-Nitroquinoline 1-oxide reacts with aluminum chloride to give 4-chloroquinoline 1-oxide. Aluminum chloride with 4-nitroquinoline 1-oxide forms a molecular complex in which it acts as electron acceptor and effective nucleophilic reagent (a source of chloride ions).
V. P. Andreev, Ya. P. Nizhnik
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In vitro transformation of hamster chondrocytes by 4-nitroquinoline 1-oxide

Cancer Letters, 1976
Hamster sternal chondrocytes were transfored morphologically in vitro 29-51 days after exposure to 4-nitroquinoline 1-oxide for 3 h. The transformed chondrocytes were randomly oriented, piled up and grew continuously. These cells produced nodules when transferred to the cheek pouch of a hamster.
Y, Katoh, S, Takayama
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