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Protective effect of Spirulina against 4-nitroquinoline-1-oxide induced toxicity
Molecular Biology Reports, 2010In the present study, we focused on the protective effect of Spirulina against 4-nitroquinoline-1-oxide (4NQO) induced hepato and nephrotoxicity in the experimental rats. The 4NQO administration resulted in increased levels of hepatic and renal markers [Alanine Transaminase (ALT), Aspartate Transaminase (AST), Lactate Dehydrogenase (LDH), urea ...
Vijaya Padma, Viswanadha +2 more
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Bioreduction of 4-nitroquinoline 1-oxide in dysplastic nevus syndrome fibroblasts
Mutation Research Letters, 1989Fibroblast strains 3012T and 3072T, derived from normal skin explants of two patients affected with familial dysplastic nevus syndrome (DNS), an hereditary variant of cutaneous malignant melanoma, have been reported to be abnormally sensitive to the cytotoxic and mutagenic effects of the procarcinogen 4-nitroquinoline 1-oxide (4NQO).
R, Mirzayans, M, Sabour, M C, Paterson
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Persistence of 4-nitroquinoline-1-oxide induced lesions in human lymphocytes
Mutation Research/DNA Repair, 1996Liquid holding (LH) recovery was matched with three-way differential staining (TWD) to assess the reduction of damage induced in DNA following treatment with 4-nitroquinoline-1-oxide (4NQO) in resting (GO) lymphocytes. Human peripheral lymphocytes (HPL) from three donors were used to evaluate lesion persistence and individual repair capacity.
Ponzanelli I +2 more
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Effects of 4-nitroquinoline 1-oxide on the DNA-protein complex
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1986The effects of 4-nitroquinoline 1-oxide (4NQO), a well known carcinogenic compound, on the DNA-protein complex and DNA Folding Proteins were investigated. FM3A cells were treated with 10(-6) M or 10(-5) M 4NQO for 30 min. Treatment with the 10(-6) M concentration was confirmed to cause the sedimentation of the DNA-protein complex to become slower.
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Liquid Chromatographic Analysis of 4-Nitroquinoline 1-Oxide and Metabolites
Journal of Liquid Chromatography, 1981Abstract High pressure liquid chromatographic (HPLC) methods for separation of the carcinogen 4-nitroquinoline 1-oxide (NQO) from its reduced metabolites, 4-hydroxyaminoquinoline 1-oxide (HAQO) and 4-aminoquinoline 1-oxide (AQO), are described. Simultaneous fluorescence and U.V.
Howard Lund +4 more
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Prevention of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by garlic
Fitoterapia, 2001The present study was undertaken to examine the inhibitory effect of garlic (Allium sativum) on 4-nitroquinoline 1-oxide (4NQO)-induced tongue carcinogenesis in male rats, both in the initiation and post-initiation phases. Lipid peroxidation, reduced glutathione (GSH), glutathione peroxidase (GPx), and glutathione S-transferase (GST) were used to ...
S, Balasenthil +2 more
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4-nitroquinoline-1-oxide: A good mutagen for Aspergillus nidulans
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1977Abstract Conditions for using 4-nitroquinoline-1-oxide as a mutagen for Aspergillus nidulans were established. High frequencies of mutations (about 0.5%) and a broad spectrum of mutants were obtained. The stability of NQO in solutions and safety precautions are described.
Jerzy Bal +2 more
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Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats
Cancer Letters, 2005The effects of dietary feeding with a polyisoprenylated benzophenone, garcinol, isolated from Garcinia indica fruit rind on the development of 4-nitroquinoline 1-oxide (4-NQO)-induced oral carcinogenesis were investigated in male F344 rats. At 7 weeks of age, animals were given 4-NQO at 20 ppm in the drinking water for 8 weeks to induce tongue ...
Koujiro, Yoshida +9 more
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Chemistry and biological actions of 4-nitroquinoline 1-oxide
Journal of Molecular Structure, 1972openaire +1 more source