Results 31 to 40 of about 7,822 (231)

Ultrastructure and biochemical function of the mitochondria in respiratory-deficient mutant yeast induced by 4-nitroquinoline nitrogen oxide [PDF]

, 1969
1. A respiratory-deficient mutant strain of yeast was obtained from wild strain of Saccharomyces servisiae by treatment with 4-nitroquinoline N-oxide. Ultrastructure and function of the wild or mutant strains and the mitochondrial fractions isolated from
Goto, Nobuyuki, Koshiba, Kimikazu, Oda, Takuzo, Tsukamoto, Hiromichi   +3 more
core   +1 more source

Taiwanin E Induces Cell Cycle Arrest and Apoptosis in Arecoline/4-NQO-Induced Oral Cancer Cells Through Modulation of the ERK Signaling Pathway

Frontiers in Oncology, 2019
Taiwanin E is a bioactive compound extracted from Taiwania cryptomerioides Hayata. In this research endeavor, we studied the anti-cancer effect of Taiwanin E against arecoline and 4-nitroquinoline-1-oxide-induced oral squamous cancer cells (OSCC), and ...
Shih-Hao Wang, Shih-Hao Wang, Hsi-Chin Wu, Khan Farheen Badrealam, Yueh-Hsiung Kuo, Yueh-Hsiung Kuo, Yueh-Hsiung Kuo, Yun-Peng Chao, Hsi-Hsien Hsu, Hsi-Hsien Hsu, Da-Tian Bau, Vijaya Padma Viswanadha, Yi-Hui Chen, Pei-Jei Lio, Chung-Jen Chiang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang   +19 more
doaj   +1 more source

Oncolytic activity of naturally attenuated herpes-simplex virus HF10 against an immunocompetent model of oral carcinoma

Molecular Therapy: Oncolytics, 2021
Prognosis for advanced oral carcinoma remains poor. Oncolytic virotherapy uses replication-competent viruses to infect and kill only the tumor cells. However, it has been difficult to investigate the oncolytic activity of viruses against oral carcinomas ...
Gaku Takano, Shinichi Esaki, Fumi Goshima, Atsushi Enomoto, Yoshimi Hatano, Haruka Ozaki, Takahiro Watanabe, Yoshitaka Sato, Daisuke Kawakita, Shingo Murakami, Takayuki Murata, Yukihiro Nishiyama, Shinichi Iwasaki, Hiroshi Kimura   +13 more
doaj   +1 more source

The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging

Frontiers in Oncology, 2021
An increased accumulation of immune-dysfunction-associated CD4+Foxp3+ regulatory T cells (Tregs) is observed in aging oral mucosa during infection. Here we studied the function of Tregs during oral cancer development in aging mucosa.
Natarajan Bhaskaran, Sangeetha Jayaraman, Cheriese Quigley, Prerna Mamileti, Mahmoud Ghannoum, Mahmoud Ghannoum, Aaron Weinberg, Aaron Weinberg, Jason Thuener, Quintin Pan, Quintin Pan, Pushpa Pandiyan, Pushpa Pandiyan, Pushpa Pandiyan   +13 more
doaj   +1 more source

4NQO Carcinogenesis: A Model of Oral Squamous Cell Carcinoma [PDF]

, 2012
Martinez, CAR (reprint author), Univ Talca, Edificio Dept Ciencias Basicas Biomed, Ave Lircay S-N,Oficina 1, Talca, Chile.The experimental oral carcinogenesis induced by the chemical 4-nitroquinoline 1-oxide (4NQO) is one of the most frequent in the ...
Martinez, C.A.R.
core   +1 more source

Squamous cell carcinoma of the tongue in Sprague-Dawley rats using 4-nitroquinoline 1-oxide model

Padjadjaran Journal of Dentistry, 2016
Background. 4-nitroquinoline 1-oxide (4NQO) is a water soluble carcinogen which is often used to induce cancer in oral cavity. Objective. The purpose of this study was to know the incidence of histopathological lesions in the tongue of rats after ...
Erni Erfan, Nafrialdi N., Puspita Ekawuyung   +2 more
doaj   +1 more source

Combination Treatment of TRPV4 Agonist with Cisplatin Promotes Vessel Normalization in an Animal Model of Oral Squamous Cell Carcinoma

Medicina, 2022
Background and Objectives: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in the world. Transient receptor potential vanilloid 4 (TRPV4) channel has been shown to be involved in angiogenesis in multiple types of tumors.
Farhana Yahya, Marina Mohd Bakri, Mohammad Zakir Hossain, Syarifah Nur Syed Abdul Rahman, Aied Mohammed Alabsi, Anand Ramanathan   +5 more
doaj   +1 more source

The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. [PDF]

, 2016
A better understanding of the dynamics of molecular changes occurring during the early stages of oral tumorigenesis may help refine prevention and treatment strategies.
Bertolus, Chloé, Caulin, Carlos, Chabaud, Sylvie, Foy, Jean-Philippe, Goudot, Patrick, Hong, Waun Ki, Lachuer, Joël, Lang, Wenhua, Lavergne, Emilie, Le Texier, Vincent, Lippman, Scott M, Perol, David, Saintigny, Pierre, Thomas, Emilie, Tortereau, Antonin   +14 more
core   +1 more source

Novel Genes Involved in Resistance to Both Ultraviolet Radiation and Perchlorate From the Metagenomes of Hypersaline Environments

Frontiers in Microbiology, 2020
Microorganisms that thrive in hypersaline environments on the surface of our planet are exposed to the harmful effects of ultraviolet radiation. Therefore, for their protection, they have sunscreen pigments and highly efficient DNA repair and protection ...
María Lamprecht-Grandío, Marta Cortesão, Salvador Mirete, Macarena Benguigui de la Cámara, Carolina G. de Figueras, Danilo Pérez-Pantoja, Joseph John White, María Eugenia Farías, Ramon Rosselló-Móra, José Eduardo González-Pastor   +9 more
doaj   +1 more source

Yeast Ribonucleotide Reductase Is a Direct Target of the Proteasome and Provides Hyper Resistance to the Carcinogen 4-NQO

Journal of Fungi, 2023
Various external and internal factors damaging DNA constantly disrupt the stability of the genome. Cells use numerous dedicated DNA repair systems to detect damage and restore genomic integrity in a timely manner.
Daria S. Spasskaya, Kirill A. Kulagin, Evgenia N. Grineva, Pamila J. Osipova, Svetlana V. Poddubko, Julia A. Bubis, Elizaveta M. Kazakova, Tomiris T. Kusainova, Vladimir A. Gorshkov, Frank Kjeldsen, Vadim L. Karpov, Irina A. Tarasova, Dmitry S. Karpov   +12 more
doaj   +1 more source