Results 61 to 70 of about 7,822 (231)

The influence of sleep deprivation on expression of apoptosis regulatory proteins p53, bcl-2 and bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

Dental Research Journal, 2013
Background: The aim of this study was to evaluate whether paradoxical sleep deprivation could affects the mechanisms and pathways essentials for cancer cells in tongue cancer induced by 4-nitroquinole 1-oxide in Wistar rats.
Juliana Noguti, Tathiana Aparecida Alvarenga, Mônica Levy Andersen, Sergio Tufik, Celina Tijuko Fujiyama Oshima, Daniel Araki Ribeiro   +5 more
doaj   +1 more source

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

A competition between N---O and C---O through space interactions in the crystal structures of 3,3'-dinitro-2,2'-bipyridine N-oxides and N,N'-dioxides [PDF]

, 2007
The crystal structures of a series of 3,3’-dinitro-2,2’-bipyridine N-oxides and N,N’-dioxides consistently show 1,5 interactions between nitro oxygen atoms and aromatic carbon atoms ((ON)O---C: 2.623(2)-2.839(2) Å) while there are also 1,6 interactions ...
O'Leary, J, Wallis, JD
core  

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

Spatial transcriptomic analysis of 4NQO-induced tongue cancer revealed cellular lineage diversity and evolutionary trajectory

Frontiers in Oncology
IntroductionSpatial transcriptomic analysis has proposed valuable insights into the behavior of tongue cancer. However, the specific cell types involved in chemically-induced carcinogenesis and the process of tumor development remain elusive.MethodsWe ...
Feng Liu, Feng Liu, Xiaojun Wu, Shaoqing Yu, Deqiang Cheng, Jun Pan, Xiaodong Wang, Guanzhen Yu, Guanzhen Yu, Chaofu Li   +9 more
doaj   +1 more source

Oral cancer: role of the basement membrane in invasion [PDF]

, 1999
The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Invasive growth of cancer cells is a complex process involving specific interactions between tumour cells
Howeedy AA, Johnson NW., Lee AK., Liotta LA., Russo P., Timpl R., Tsujioka Y., Wallenius K., Wiebkin OW., Wilson DF, Wong SY   +10 more
core   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

A microscopy-based screen employing multiplex genome sequencing identifies cargo-specific requirements for dynein velocity [PDF]

, 2014
The timely delivery of membranous organelles and macromolecules to specific locations within the majority of eukaryotic cells depends on microtubule-based transport.
Abenza JF, Anthony J. Roberts, Bailleul B, Barbour L, Cho C, Eckley DM, Egan MJ, Egan MJ, Erzberger JP, Fernandez-Abalos JM, Galagan J, Gero Steinberg, Gibson DG, Hammer JA, Hendricks AG, Huang J, Ikenaga M, Imamula K, Kaeling Tan, Kon T, Laan L, Lee SB, Lefrancois P, Lenz JH, Li H, Li H, Ligon LA, Malone CJ, Mark Chonofsky, Martin J. Egan, McKenna A, Meyer M, Morris NR, Murakami K, Nayak T, Orr-Weaver TL, Perlson E, Qiu W, Reck-Peterson SL, Requena N, Samara L. Reck-Peterson, Schafer DA, Schmidt H, Seidel C, Shaner NC, Sivagurunathan S, Subach OM, Szewczyk E, Todd RB, Todd RB, Vogel SK, Wortman JR, Xiang X, Xiang X, Zhang J, Zhang J   +55 more
core   +3 more sources

Interactions of 4-nitroquinoline-1-oxide with nucleic acids

, 1979
Stephen A. Winkle
openalex   +3 more sources

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source