Results 81 to 90 of about 7,822 (231)

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source

The influence of organic solvents on estimates of genotoxicity and antigenotoxicity in the SOS chromotest

Genetics and Molecular Biology, 2012
In this work, the toxicity and genotoxicity of organic solvents (acetone, carbon tetrachloride, dichloromethane, dimethylsulfoxide, ethanol, ether and methanol) were studied using the SOS chromotest.
Nathalia Quintero, Elena E. Stashenko, Jorge Luis Fuentes   +2 more
doaj   +1 more source

N4-acetylcytidine-dependent GLMP mRNA stabilization by NAT10 promotes head and neck squamous cell carcinoma metastasis and remodels tumor microenvironment through MAPK/ERK signaling pathway

Cell Death and Disease, 2023
N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that regulates in various important biological processes. However, its role in human cancer, especially lymph node metastasis, remains largely unknown.
Yuanyuan Liu, Xing Wang, Yuying Liu, Jianqiang Yang, Wei Mao, Chen Feng, Xiaoliang Wu, Xinwei Chen, Lixiao Chen, Pin Dong   +9 more
doaj   +1 more source

Damage-induced phosphorylation of Sld3 is important to block late origin firing. [PDF]

, 2010
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion.
Defazio-Eli, Lisa G, Jonsson, Zophonias O, Lopez-Mosqueda, Jaime, Maas, Nancy L, Toczyski, David P, Wohlschlegel, James   +5 more
core   +2 more sources

Single‐Cell RNA‐Seq Reveals the Effect of Commensal Bacteria on the Multistep Development of Esophageal Cancer

Cancer Science, Volume 116, Issue 12, Page 3337-3351, December 2025.
These results shed light on the impact of commensal microbiome on phenotypes and transition fates of different cell types across the tumorigenic processes of ESCC and may have implications for ESCC prevention and treatment. ABSTRACT Microbiomes within the tumor microenvironment (TME) are intricately linked to the modulation of cancer cell properties ...
Xuan Xie, Shuyue Zhang, Zihang Mai, Jing Zhan, Sheng Lei, Zhiqiang Ouyang, Zelin Weng, Xiuying Xie, Jingjing Han, Jing Wen   +9 more
wiley   +1 more source

Safety evaluation of jagua (genipin‐glycine) blue as a food additive

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety of jagua (genipin‐glycine) blue as a new food additive. Jagua (genipin‐glycine) blue is obtained by water extraction of the ground pulp of the peeled, unripe fruits of Genipa americana L.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, José Manuel Barat Baviera, Gisela Degen, David Gott, Jean‐Charles Leblanc, Peter Moldeus, Ine Waalkens‐Berendsen, Detlef Wölfle, Consuelo Civitella, Agnieszka Mech, Concepción Medrano‐Padial, Alexandra Tard, Panagiota Zakidou, Laura Ruggeri   +29 more
wiley   +1 more source

The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma [PDF]

, 2017
Multipotent stromal cells (MSCs) are envisioned as a powerful therapeutic tool. As they home into tumors, secrete trophic and vasculogenic factors, and suppress immune response their role in carcinogenesis is a matter of controversy.
Arango Rodríguez, Martha, Bruna, Flavia Alejandra, Conget, Paulette, Espinoza, Iris, Plaza, Anita   +4 more
core   +1 more source

Copper‐Catalyzed Hydrosilylation of Nitroarenes: Chemoselective Reduction to Aromatic Amines

ChemCatChem, Volume 17, Issue 22, November 24, 2025.
A commercially available copper‐hydride complex was utilized as an effective catalyst for the hydrosilylation of nitroarenes to aromatic amines. Nitroarenes with diverse functionalities were efficiently reduced to anilines with good chemoselectivity. The practicality of this reduction protocol was demonstrated through the synthesis of pharmaceuticals ...
Pritirekha Mallick, Ratiraman Swain, Swetarani Meher, Subrat Sethi, Bidraha Bagh   +4 more
wiley   +1 more source

Morphology and growth patterns of colonies of liver cell lines derived from rats fed with 4-dimethylaminoazobenzene [PDF]

, 1970
Morphological comparison at colonial level was made on a series of established liver cell lines derived from rats fed 4-dimethylaminoazo-benzene (DAB) for various periods of days for the purpose of elucidating more accurately the differences in ...
Chikata, Eiji
core   +1 more source

Genotoxicity of tamoxifen citrate and 4‐nitroquinoline‐1‐oxide in the wing spot test of Drosophila melanogaster [PDF]

, 2017
Tamoxifen (TAM) is an anti‐oestrogen used for treatment and prevention of human breast cancer, but it is also related to human endometrial and uterine cancer.
Castañeda‐Partida, Laura, Contreras‐Sousa, Martha, Dueñas‐García, Irma, Durán‐Díaz, Ángel, Graf, Ulrich, Heres‐Pulido, M.Eugenia, Sánchez‐García, Antonio   +6 more
core