Results 201 to 210 of about 10,060,116 (342)

ESFA Update further education: 4 March 2020 [PDF]

, 2020

core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An economic analysis of the impact of education on health behaviours and health outcomes in South Africa: a case of Amathole District Municipality and Buffalo City Metropolitan Municipality. [PDF]

Health Econ Rev
Hlafa B, Tsegaye A, Dickson M, Hompashe DM.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Generating multiple-choice questions using reverse engineering techniques. [PDF]

Med Educ Online
Shin S, Choi J, Hong E, Lee M, Lee M.
europepmc   +1 more source

Implementation of Islamic Religious Education Learning Evaluation Through Daily Tests on Students' Learning Motivation UPTD SMP Negeri 4 Parepare

, 2023
Evi Febrianti, Makki, Rosmiati Ramli, Andi Fitriani Djollong, Muhammad Nur Maallah   +4 more
openalex   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Innovating Built Environment Education to Achieve SDG 4: Key Drivers for Integrating Augmented Reality Technologies

Opeoluwa Akinradewo, Mohammed M. Hafez, Clinton Aigbavboa, Andrew Ebekozien, Peter Adekunle, Osamudiamen Otasowie   +5 more
openalex   +1 more source

Multiculturalism, Interculturality and Diversity in Education. An Anthropological Approach. Par Gunther Dietz (München, Waxmann, 2009. Pp. 183, ISBN 978-3-8309-2197-4) [PDF]

, 2010
Stéphanie Arsenault
openalex   +1 more source