Results 101 to 110 of about 8,196,263 (389)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Regional wage convergence in Spain : 1850-1930 [PDF]
, 2002 Real wages PPP adjusted are used to analyse labour market integration in Spain. In contrast to earlier research analysing migration and nominal wages rates, our research seems to indicate that a well-integrated labour market had emerged in Spain by 1914 ...
Rosés, Joan R., Sánchez-Alonso, Blanca
core +1 more source
Nuclear Materials and Energy, 2020 Ion irradiations are indispensable for exploring radiation effects on materials, for example, radiation hardening. However, the extraction of radiation hardening as function of displacement damage from the nanoindentation (NI) response of self-ion ...
K. Vogel +5 more
doaj
E-Journal of Chemistry, 2008 A rapid, sensitive and specific method to quantify cinitapride in human plasma using risperidone as the internal standard is described. Sample preparation involved simple solid phase extraction procedure.
Shikha M. N. Roy +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Somatic cell count and major elements in milk during lactation in buffaloes
Indian Journal of Animal Sciences, 2014 Apparently healthy Murrah buffaloes (18) were divided equally into early, mid-and late lactation stages. The difference in somatic cell count amongst three stages of lactation were statistically highly significant. The milk somatic cell counts increased
S S MANAGULI +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
A left-handed blow : writing the history of animals [PDF]
, 2002 This chapter looks at writing the history of ...
Fudge, Erica
core