Results 91 to 100 of about 7,930,796 (309)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Sequential Therapy in Metastatic Renal Cell Carcinoma
Journal of Kidney Cancer and VHL, 2016 The treatment of metastatic renal cell carcinoma (mRCC) has changed dramatically in the past decade. As the number of available agents, and related volume of research, has grown, it is increasingly complex to know how to optimally treat patients.
Bradford R Hirsch +7 more
doaj +1 more source
Understanding Solar Activity During the Last 400 Years [PDF]
, 2019 The solar cycle has a profound effect on both terrestrial and extra-terrestrial operations. Understanding the history of the solar cycle is necessary for studying long term trends, however older data is difficult to calibrate due to the sparsity of ...
Hollenbach, Sam Q
core +1 more source
Gamma-Ray Burst Spectra and Time Histories from 2 to 400 keV [PDF]
, 1998 The Gamma-Ray burst detector on Ginga consisted of a proportional counter to observe the x-rays and a scintillation counter to observe the gamma-rays. It was ideally suited to study the x-rays associated with gamma-ray bursts (GRBs).
Band +18 more
core +4 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Somatic cell count and major elements in milk during lactation in buffaloes
Indian Journal of Animal Sciences, 2014 Apparently healthy Murrah buffaloes (18) were divided equally into early, mid-and late lactation stages. The difference in somatic cell count amongst three stages of lactation were statistically highly significant. The milk somatic cell counts increased
S S MANAGULI +3 more
doaj +1 more source
Radio frequency science considerations [PDF]
, 1974 Use of the 400 MHz telecommunications system to obtain scientific information, to provide backup information for the experiments flown, and to obtain measurements which aid in designing future probes is considered.
Croft, T. A.
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source