Results 71 to 80 of about 2,452,040 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Electrochemical studies on the corrosion inhibition efficiency of 3,4-diphenyl-2,5-thiophenedicarboxylic acid for mild steel in 1 M HCl

Next Materials
The present work reports, for the first time, the corrosion inhibition performance of 3,4-diphenyl-2,5-thiophenedicarboxylic acid, a newly designed thiophene-based dicarboxylic acid, on mild steel in 1 M HCl solution.
Sai P. Katke, Sanket S. Mohite, Jaydeep S. Yadav, Rohit D. Chaurasiya   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Thermal stability of limestone calcined clay cement (LC3) at moderate temperatures 100–400 °C

, 2023
The mechanical properties, phase evolution, microstructure development and (re)hydration properties of limestone calcined clay cement (LC3) paste and mortar were investigated to understand their thermal stability under moderate temperatures (100–400 °C).
Cao, Yubin, Ma, Yuwei, Zhang, Zuhu, Wang, Yanru, Wang, Hao   +4 more
core   +1 more source

Planteamiento de realización

Informes de la Construccion, 1989
El Planeamiento para el diseño, construcción y puesta en marcha del Tanque de GNL de la Terminal de Palos de la Frontera (Huelva) se ha basado en un sistema de contratación llave en mano a un solo contratista que adquiera la responsabilidad completa con ...
Luis Fort López-Tello
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

UMP tersenarai di kedudukan 301 400 THE University Impact Rankings 2023 [PDF]

, 2023
KUANTAN, 2 Jun 2023 - Universiti Malaysia Pahang (UMP) berada di kedudukan 301-400 terbaik dunia daripada 1,591 universiti seluruh dunia dan ketujuh terbaik di Malaysia dalam penarafan Times Higher Education (THE) University Impact Rankings yang ...
Mimi Rabita, Abdul Wahit
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

CSM-400 - Multi-agent Foreign Exchange Market Modelling via GP [PDF]

, 2004
In this work we combine Genetic Programming (GP) and intelligent agents to build a realistic foreign exchange currency market simulator. GP is used to express and evolve trading strategies.
Dignum, S, Poli, R
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source