Results 61 to 70 of about 2,452,040 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Emerging Vistas for the Nutraceutical Withania somnifera in Inflammaging

Pharmaceuticals
Inflammaging, a coexistence of inflammation and aging, is a persistent, systemic, low-grade inflammation seen in the geriatric population. Various natural compounds have been greatly explored for their potential role in preventing and treating ...
Vivek Basudkar, Gunjan Gujrati, Saiprasad Ajgaonkar, Manav Gandhi, Dilip Mehta, Sujit Nair   +5 more
doaj   +1 more source

Interaction of nanosecond laser pulse with tetramethyl silane (Si(CH3)4) clusters: Generation of multiply charged silicon and carbon ions

AIP Advances, 2011
Present work reports significantly high levels of ionization, eventually leading to Coulomb explosion of Tetramethyl silane (TMS) clusters, on interaction with laser pulses of intensity ∼109 W/cm2.
Purav M. Badani, Soumitra Das, Venkateswara Rao Mundlapati, Pramod Sharma, Rajesh K. Vatsa   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of Radical‐Mediated Cross‐Linking on Partially Fluorinated Aromatic Anion Exchange Membranes and their Applications in Alkaline Water Electrolysis Cells

Advanced Energy & Sustainability Research
To investigate the effect of cross‐linking on partially fluorinated anion exchange membranes tethered with trimethylpropyl side chains (QPAF‐C3), styrene‐based cross‐linker is introduced into the precursor copolymers and then cross‐linked via free ...
Ahmed Mohamed Ahmed Mahmoud, Kenji Miyatake, Fanghua Liu, Vikrant Yadav, Lin Guo, Chun Yik Wong, Toshio Iwataki, Katsuyoshi Kakinuma, Makoto Uchida   +8 more
doaj   +1 more source

Determination of Free Levels of Cinitipride in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry

E-Journal of Chemistry, 2008
A rapid, sensitive and specific method to quantify cinitapride in human plasma using risperidone as the internal standard is described. Sample preparation involved simple solid phase extraction procedure.
Shikha M. N. Roy, Santos H. M. Yetal, Sangita V. Chavan, Vara D. R. Pradhan, Santosh S. Joshi   +4 more
doaj   +1 more source

Mass transport induced asymmetry in charge/discharge behavior of liquid metal batteries

Electrochemistry Communications, 2019
Mass and charge transport in liquid metal batteries are closely intertwined because of the fully liquid interior of the cells. We found that charging and discharging cycles may show pronounced asymmetries.
Paolo Personnettaz, Steffen Landgraf, Michael Nimtz, Norbert Weber, Tom Weier   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Fifty Years of Development Economics: From Planning to Liberalization Essay in Honour of Prof. P.R.Brahmanande

Malaysian Management Journal, 2000
Fifty Years of Development Economics, Essays in Hon­our of Professor P.R. Brahmananda, Editors A. Vasedevan, D.M. Nachane, A.V. Karnik, Foreword Lord Meghnad Desai, Himalaya Publishing House, Mumbai 400 004, First Edition - 1999.
Vesudevan A., Nachare D.M, Karnik A.V
doaj