Results 41 to 50 of about 338,093 (288)

MicroRNA-410 suppresses migration and invasion by targeting MDM2 in gastric cancer. [PDF]

PLoS ONE, 2014
Gastric cancer is one of the most frequent malignancies in tumors in the East Asian countries. Identifying precise prognostic markers and effective therapeutic targets is important in the treatment of gastric cancer.
Jianjun Shen, Weina Niu, Ming Zhou, Hongbo Zhang, Jun Ma, Ling Wang, Hongyan Zhang   +6 more
doaj   +1 more source

Feasibility of Nitrogen as a Carrier Gas for Inconel Cold Spray in Hydropower Application

Advanced Engineering Materials, EarlyView.
N2, despite being nearly two orders of magnitude cheaper than He, is a feasible carrier gas for cold spray Inconel coatings in hydropower repair applications when higher gas temperature and pressure are used. Reducing powder size significantly improved cavitation resistance, while the addition of fine chromium carbide particles further enhanced erosion
Tianhao Wang, Mayur Pole, Tingkun Liu, Kenneth A. Ross, Christopher B. Smith   +4 more
wiley   +1 more source

Bioanalysis of the Ex Vivo Labile PACE4 Inhibitory Peptide Ac-[d-Leu]LLLRVK-Amba in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification

Pharmaceutics, 2023
The calcium-dependent serine endoprotease PACE4 is evaluated as a therapeutic target for prostate cancer. The peptide Ac-[d-Leu]LLLRVK-amba inhibits PACE4 with high affinity and has shown efficacy in preclinical mice xenograft models of prostate cancer ...
Max Sauter, Jonas Haag, Cindy Bay, Florian Leuschner, Walter E. Haefeli, Tim Christian Kuhn, Jürgen Burhenne   +6 more
doaj   +1 more source

Influence of Scan Strategies in Electron Beam Powder Bed Fusion on Solidification, Microstructure, and High‐Temperature Compressive Properties of γ′‐Strengthened Inconel 738LC

Advanced Engineering Materials, EarlyView.
Experiments and thermophysical simulations were conducted to investigate the electron beam powder bed fusion electron beam (PBF‐EB/M) process for the γ′‐strengthened nickel‐based superalloy Inconel 738LC. The results demonstrate the impact of process‐induced microstructural variations on high‐temperature mechanical behavior, providing a basis for ...
Jan Niklas Petenati, Karthik Kumar Banku, Prasanth Bondi, Ivan Zhirnov, Yangyiwei Yang, Gordon Schmidt, Jürgen Christen, Georg Hasemann, Manja Krüger, Bai‐Xiang Xu, Bilal Gökce, Silja‐Katharina Rittinghaus   +11 more
wiley   +1 more source

Multicriteria Framework for Risk Assessment of Power Transformers

Energies
Transformers are critical assets for power system reliability, as they connect different voltage levels across generation, transmission, and distribution. Their failure can lead to significant impacts on multiple aspects.
João Marcondes Corrêa Guimarães, Ligia Cintra Pereira, Antonio Faria Neto, Agnelo Marotta Cassula, Talita Mariane Cristino   +4 more
doaj   +1 more source

MicroRNA-410-3p modulates chondrocyte apoptosis and inflammation by targeting high mobility group box 1 (HMGB1) in an osteoarthritis mouse model

BMC Musculoskeletal Disorders, 2020
Background Osteoarthritis (OA) is the most prevalent type of arthritis, which commonly involves inflammation in the articular cartilage in OA pathogenesis.
Hong Pan, Huming Dai, Linzhi Wang, Silong Lin, Yuefeng Tao, Yi Zheng, Renyi Jiang, Fan Fang, Yifan Wu   +8 more
doaj   +1 more source

Titanium Suboxides Responsible for Electronic Anomaly Near Room Temperature in the Ti3C2Tx MXene

Advanced Functional Materials, EarlyView.
Our multi‐technique study reveals that the near‐room‐temperature anomaly in Ti3C2Tx MXene is linked to titanium suboxide nanodomains, including Ti3O5, embedded within the MXene host. Their temperature‐driven transformation provides an alternative explanation to solvent‐ and swelling‐based models and offers new insight into the thermally activated ...
Bence G. Márkus, Bradlee J. McIntosh, Lili Vajtai, Anna Nyáry, Sándor H. Sipos, Nirmal J. Ghimire, Ferenc Simon, László Forró, Dávid Beke   +8 more
wiley   +1 more source

Comment on essd-2022-410 [PDF]

, 2023
José V. Moris, Pedro Álvarez-Álvarez, Marco Conedera, Annalie Dorph, Thomas D. Hessilt, H. J. HUNT, Renata Libonati, Lucas S. Menezes, Mortimer M. Mà ⁄ ller, Francisco J. Pérez-Invernà n, Gianni Boris Pezzatti, Nicolau Pineda, Rebecca C. Scholten, Sander Veraverbeke, B. Mike Wotton, Davide Ascoli   +15 more
openalex   +2 more sources

MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.

PLoS ONE, 2014
FHL1 is an important tumor-suppressor that is downregulated in multiple tumors by unknown mechanisms. We demonstrated that miR-410 specifically targets the 3'UTR of FHL1.
Yu Wang, Jie Fu, Mengmeng Jiang, Xiaoai Zhang, Long Cheng, Xiaojie Xu, Zhongyi Fan, Jing Zhang, Qinong Ye, Haifeng Song   +9 more
doaj   +1 more source

Chiral Phase Change Nanomaterials

Advanced Functional Materials, EarlyView.
This work demonstrates reversible, non‐volatile phase transitions in chiral Ge2${\rm Ge}_2$Sb2${\rm Sb}_2$Te5${\rm Te}_5$ (GST) nanohelices for high‐speed optical modulation of chirality and dynamic control of the state of polarization (SOP). The chiral nanostructures are fabricated using a highly directional, wafer‐scale physical vapor deposition ...
Joshua A. Burrow, Md Shah Alam, Riad Yahiaoui, Evan M. Smith, Ryan Laing, Jules Gardener, Thomas A. Searles, Piyush J. Shah, Shivashankar Vangala, Joshua R. Hendrickson, Andrew M. Sarangan, Imad Agha   +11 more
wiley   +1 more source