Results 1 to 10 of about 88 (70)

Safe and potent anti-CD19 CAR T-cells with shRNA-IL-6 gene silencing element in patients with refractory or relapsed B-cell acute lymphoblastic leukemia. [PDF]

Hemasphere
Abstract Severe cytokine release syndrome (sCRS) and immune effector cell‐associated neurotoxicity syndrome (ICANS) have limited the widespread use of chimeric antigen receptor T (CAR T)‐cell therapy. We designed a novel anti‐CD19 CAR (ssCART‐19) with a small hairpin RNA (shRNA) element to silence the interleukin‐6 (IL‐6) gene, hypothesizing it could ...
Ma JF, Yan JW, Liu MJ, Yan CL, Tang XW, Qiu HY, Miao M, Han Y, Li LM, Kang LQ, Xu N, Yu Z, Tan JW, Zhu HJ, Jia X, Zhang ZZ, Wang M, Dai HP, Yu L, Xue SL, Wu DP, Gong WJ.   +21 more
europepmc   +2 more sources

Utility of Machine Learning Algorithms in Predicting Preoperative Lymph Node Metastasis in Patients With Rectal Cancer Based on Three‐Dimensional Endorectal Ultrasound and Clinical and Laboratory Data

Journal of Ultrasound in Medicine, Volume 42, Issue 11, Page 2615-2627, November 2023., 2023
Background We aimed to investigate the value of a machine learning (ML) algorithm in the preoperative prediction of lymph node metastasis in patients with rectal cancer. Methods Based on the histopathological results, 126 rectal cancer patients were divided into two groups: lymph node metastasis‐positive and metastasis‐negative groups.
Weiqin Huang, Ruoxuan Lin, Xiaohui Ke, Shixiong Ni, Zhen Zhang, Lina Tang   +5 more
wiley   +1 more source

Natural Vegetation Succession Under Climate Change and the Combined Effects on Net Primary Productivity

Earth's Future, Volume 11, Issue 11, November 2023., 2023
Abstract Climate change and the resulting natural vegetation succession can alter vegetation productivity. However, the mechanisms underlying future productivity changes under the two influences remain unclear. Here, we used the comprehensive sequence classification system to simulate changes in global potential natural vegetation under different ...
Sen Zhang, Xingming Hao, Zhuoyi Zhao, Jingjing Zhang, Xue Fan, Xuewei Li   +5 more
wiley   +1 more source

Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells

Cancer Medicine, Volume 12, Issue 11, Page 12581-12592, June 2023., 2023
Abstract Background Kinesin family member 4A (KIF4A) is upregulated in a variety of cancers. However, its expression and potential downstream targets in urothelial bladder carcinoma (UBC) remain unclear. Methods Expression data of KIF4A in UBC and noncancerous tissues were downloaded from the GEPIA database. Cell proliferation, migration, invasion, and
Chen Zhang, Maoyu Wang, Yidie Ying, Fang Meng, Hongliang Gao, Shuxiong Zeng, Yasheng Zhu, Anwei Liu, Zhensheng Zhang, Chuanliang Xu   +9 more
wiley   +1 more source

[Retracted] The Influence of the Development of the Internet of Things Industry on the Optimization of the High‐ and New‐Tech Industry Structure under the Wireless Mobile Network

Computational Intelligence and Neuroscience, Volume 2022, Issue 1, 2022., 2022
At present, the pressure on China’s economic development is increasing day by day due to the profound changes in the internal and external environment. The global economic pattern is undergoing significant changes in terms of the external environment.
Yu Liu, Zhengchao Zhang, Shicao Jiang, Yawen Yang, Rahim Khan   +4 more
wiley   +1 more source

Clinical Characteristics of Target Organ Damage in Primary Aldosteronism with or without Metabolic Syndrome

Journal of Diabetes Research, Volume 2022, Issue 1, 2022., 2022
The aim of this study is to investigate the prevalence of metabolic disorders in patients with primary aldosteronism (PA) and target organ damage (TOD) in different subtypes of patients with PA with or without metabolic syndrome (MS). Patients with PA were screened out from those with secondary hypertension and then subtyped via adrenal venous sampling
Xiaona Bu, Fang Sun, Hexuan Zhang, Xiaoli Liu, Zhigang Zhao, Hongbo He, Yingsha Li, Zhencheng Yan, Zhiming Zhu, Akira Sugawara   +9 more
wiley   +1 more source

Geochemical Characteristics of the Middle Devonian Dacaozi‐Tanshanping Shale Strata in the Yanyuan Basin, Southwest China: Implications for Organic Matter Accumulation and Preservation

Geofluids, Volume 2021, Issue 1, 2021., 2021
How the geochemical characteristics of organic matter shale for the carbonate platform facies remain uncertain, which restricts an integrated reconstruction of the model of organic matter accumulation and preservation. Here, we present new results from element geochemical fingerprinting and integrated analyses of paleoclimate, paleoproductivity ...
Ziya Zhang, Wei Yang, Xingyu Li, Yan Song, Zhenxue Jiang, Qun Luo, Martina Zucchi   +6 more
wiley   +1 more source

Efficacy of Neoadjuvant Chemotherapy DOX and XELOX Regimens for Patients with Resectable Gastric or Gastroesophageal Junction Adenocarcinoma

Gastroenterology Research and Practice, Volume 2021, Issue 1, 2021., 2021
Purpose. This paper is aimed at comparing the short‐term efficacy of the combination of docetaxel, oxaliplatin, and capecitabine (DOX) with the combination of oxaliplatin and capecitabine (XELOX) as neoadjuvant chemotherapy regimens for the treatment of patients with resectable gastric or gastroesophageal junction adenocarcinoma. Methods.
Yuan Tian, Qun Zhao, Yong Li, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Bibo Tan, Dong Wang, Peigang Yang, Nicola Silvestris   +9 more
wiley   +1 more source

Characteristics and Meteorological Factors of Severe Haze Pollution in China

Advances in Meteorology, Volume 2021, Issue 1, 2021., 2021
A severe haze pollution incident caused by unfavorable weather conditions and a northern air mass occurred in eastern, northern, northwestern, and southwestern China from January 15 to January 22, 2018. To comparatively analyze variations in PM2.5 pollution, hourly monitoring data and 24 h meteorological data were collected.
Chao He, Song Hong, Hang Mu, Peiyue Tu, Lu Yang, Biqin Ke, Jiayi Huang, Herminia García Mozo   +7 more
wiley   +1 more source

ZnO nanorod array random lasers fabricated by a laser-induced hydrothermal synthesis

New Journal of Physics, 2016
We demonstrate random lasing in ZnO nanorod array (NRA) structures fabricated by a laser-induced hydrothermal growth, which would make it possible to control structural parameters, such as diameter, length, density and so on, by adjusting the laser ...
Hideki Fujiwara, Takemasa Suzuki, Ryo Niyuki, Keiji Sasaki   +3 more
doaj   +1 more source