Results 101 to 110 of about 1,946,969 (304)

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

TorchSim: an efficient atomistic simulation engine in PyTorch

AI for Science
We introduce TorchSim, an open-source atomistic simulation engine tailored for the machine learned interatomic potential (MLIP) era. By rewriting core atomistic simulation primitives in PyTorch, TorchSim can achieve orders of magnitude acceleration for ...
Orion Cohen, Janosh Riebesell, Rhys Goodall, Adeesh Kolluru, Stefano Falletta, Joseph Krause, Jorge Colindres, Gerbrand Ceder, Abhijeet S Gangan   +8 more
doaj   +1 more source

Asset prices and omitted moments; A stochastic dominance analysis of market efficiency [PDF]

We analyze if the value-weighted stock market portfolio is second-order stochastic dominance (SSD) efficient relative to benchmark portfolios formed on market capitalization, book-to-market equity ratio and industry classification. During the period from
Post, G.T.
core   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Simulating water-limited potato yields across the Netherlands with (SWAP-)WOFOST: Experimentation, model improvement and evaluation

Agricultural Water Management
Water availability explains a large part of the spatial and temporal yield variability of ware potato in the Netherlands. Climate change is projected to lead to greater variability in water availability. Therefore, an accurate simulation of crop yield as
Tamara ten Den, Arie P.P. Ravensbergen, Inge van de Wiel, Allard de Wit, Frits K. van Evert, Martin K. van Ittersum, Pytrik Reidsma   +6 more
doaj   +1 more source

Comparison of reflectivity and wind profiles measured on 46.8 MHz and 430 MHz at the Arecibo Observatory [PDF]

, 1986
Comparisons of troposphere and stratosphere radar experiments at ultrahigh frequency (UHF) and very high frequency (VHF) were done at the Arecibo Observatory in April 1980 with the 430 MHz and 46.8 MHz radar.
Rottger, J.
core   +1 more source

Efficient generation of highly squeezed light and second harmonic wave with periodically poled MgO:LiNbO_3

, 2009
We report on effective generation of continuous-wave squeezed light and second harmonics with a periodically poled MgO:LiNbO$_{\mathrm{3}}$ (PPMgLN) crystal which enables us to utilize the large nonlinear optical coefficient $d_{\mathrm{33}}$.
Akira Furusawa, Boyd, Braunstein, Drever, Feng, Furusawa, Genta Masada, Hideki Ishizuki, Ishizuki, Lawrence, Mehmet, Polzik, Shoji, Suzuki, Takeno, Takunori Taira, Tsuyoshi Suzudo, Yasuhiro Satoh, Yoshino, Zhang   +19 more
core   +1 more source

Temporally Delayed Deployment of Photo‐Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces

Advanced Healthcare Materials, EarlyView.
Deployable medical devices typically need external stimuli to trigger deployment. However, external stimuli are difficult to supply within tissues. Here, we describe a strategy to deploy small‐scale structures into soft tissues after insertion without the need for any stimulus. We demonstrate deployment within a tissue phantom.
Yeh‐Chia Tseng, Eleanor Nguyen Jeakle, Mahjabeen Javed, Rajasree Gopala Krishnan, Thomas J. Smith, Yoo Jin Lee, Sahana Dhananjayan, Sasha M. George, Manivannan Sivaperuman Kalairaj, Ali Hasan Zuaiter, Majed O. Althumayri, Hatice Ceylan Koydemir, Joseph J. Pancrazio, Taylor H. Ware   +13 more
wiley   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source