Results 81 to 90 of about 396,810 (295)

Wall parameters in a carotid bifurcation phantom: comparison of 4D flow MRI measurements with computational fluid dynamics

, 2023
Internal carotid artery (ICA) stenoses are a major source of stroke. Besides cardiovascular risk factors, plaque composition, and carotid bifurcation geometry, hemodynamic wall parameters (e.g., wall shear stress, WSS) are additional risk factors for the
Jung, Bernd, Mokhtari, Ali, Obrist, Dominik, Harloff, Andreas, Corso, Pascal   +4 more
core  

4D Flow MRI hemodynamic benchmarking of surgical bioprosthetic valves [PDF]

, 2020
Purpose: We exploited 4-dimensional flow magnetic resonance imaging (4D Flow), combined with a standardized in vitro setting, to establish a comprehensive benchmark for the systematic hemodynamic comparison of surgical aortic bioprosthetic valves (BPVs).
Lucherini F., Siryk S. V., Menicanti L., Redaelli A., Piatti F., Pluchinotta F. R., Jaworek M., Lombardi M., Giese D., Vismara R., Sturla F., Tasca G.   +11 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Highly accelerated compressed-sensing 4D flow for intracardiac flow assessment

, 2022
Background: Four-dimensional (4D) flow MRI allows for the quantification of complex flow patterns; however, its clinical use is limited by its inherently long acquisition time.
Xiong, Fei, Emrich, Tilman, Kreitner, Karl-Friedrich, Ese, Amir, Varga-Szemes, Akos, Düber, Christoph, Kilburg, Anton, Aquino, Gilberto, Dargis, Danielle M., Markl, Michael, Halfmann, Moritz, Jin, Ning, Schoepf, Joseph   +12 more
core   +1 more source

4D flow MRI: value and clinical perspectives in patients with pathology of the heart and great vessels (part 2): A review [PDF]

Терапевтический архив
The study of blood flow is becoming a new trend in cardiology and cardiovascular surgery. Based on the literature and our own data, a review is presented on the use of 4D flow in diseases of the heart and blood vessels.
Lyudmila A. Yurpolskaya
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Assessment of flow pattern of right ventricle outflow and pulmonary arteries in surgically corrected tetralogy of Fallot patients by four-dimensional cardiac magnetic resonance flow

The Egyptian Heart Journal, 2020
Background The most common post-surgical complication of tetralogy of Fallot (TOF) is pulmonary regurgitation (PR) which can lead to right ventricle (RV) dysfunction/failure. Cardiac magnetic resonance (CMR) is the imaging modality of choice to follow-up
Mahmoud Shaaban, Mai Salama, Ayman Alsaied, Raghda Elsheikh, Magdy Elmasry   +4 more
doaj   +1 more source

Synthesis of patient-specific multipoint 4D flow MRI data of turbulent aortic flow downstream of stenotic valves

Scientific Reports, 2022
We propose to synthesize patient-specific 4D flow MRI datasets of turbulent flow paired with ground truth flow data to support training of inference methods.
Pietro Dirix, Stefano Buoso, Eva S. Peper, Sebastian Kozerke   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source