Results 61 to 70 of about 1,250,528 (295)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Information in 4D-STEM: Where it is, and How to Use it

Ultramicroscopy
45 pages, 10 figures; corrected typos; submitted to ...
Desheng Ma, Guanxing Li, David A. Muller, Steven E. Zeltmann   +3 more
openaire   +3 more sources

Phase Object Reconstruction for 4D-STEM using Deep Learning [PDF]

, 2022
In this study we explore the possibility to use deep learning for the reconstruction of phase images from 4D scanning transmission electron microscopy (4D-STEM) data. The process can be divided into two main steps.
Friedrich, Thomas, Verbeeck, Jo, Verbeeck, Johan, Yu, Chu-Ping, Van Aert, Sandra, Sandra Van Aert, Thomas Friedrich, Chu-Ping Yu, Johan Verbeeck   +8 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A Unified preprocessing framework for high-throughput diffraction pattern analysis

npj Computational Materials
Four-dimensional scanning transmission electron microscopy (4D-STEM) is a high-throughput automated data acquisition technique with great potential for real-time data collection and analysis in automated STEM.
Mingyu Liu, Zian Mao, Zhu Liu, Jintao Guo, Haoran Zhang, Xi Huang, Chun Cheng, Jun Ding, Jian Hui, Shufen Chu, Xiaoqin Zeng, Yujun Xie   +11 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Limbal stem cells carried by a four-dimensional -printed chitosan-based scaffold for corneal epithelium injury in diabetic rabbits

Frontiers in Physiology
Methods: Herein, we obtained and characterized deltaN p63- and adenosine triphosphate-binding cassette subfamily G member 2-expressing limbal stem cells (LSCs).
Mengyuan Wang, Kaibin Liu, Xiaomin Wang, Zhen Shang, Yiming Liu, Nailong Pan, Xueqing Sun, Wenhua Xu   +7 more
doaj   +1 more source

Robust local thickness estimation of sub-micrometer specimen by 4D-STEM [PDF]

, 2023
We present a quantitative four-dimensional scanning transmission electron microscopy (4D-STEM)imaging technique (q4STEM) for local thickness estimation across amorphous specimen such asobtained by focused ion beam (FIB)-milling of lamellae for (cryo-)TEM
Vladislav, Krzyzanek, Radim, Skoupy, Daan B., Boltje, Tomas, Laznicka, Katerina, Mrazova, Miroslav, Slouf, Jacob P., Hoogenboom, Clémence M., Taisne, Arjen J., Jakobi, Tomas Laznicka, Jacob P. Hoogenboom, Clémence M. Taisne, Miroslav Slouf, Daan B. Boltje, Arjen J. Jakobi, Radim Skoupy, Vladislav Krzyzanek, Katerina Mrazova   +17 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source