Results 91 to 100 of about 21,523 (223)
Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery
Advanced Science, Volume 13, Issue 20, 9 April 2026.Illustration summarizes how human intestinal organoids (HIOs) are becoming transformative in preclinical research. Preclinical drug discovery pipelines often rely on animal models for ADMET studies, even though interspecies ADME gaps, poor external validity, and high attrition rates are common.
Debarun Patra +6 more
wiley +1 more source
Update on the management of ulcerative colitis: treatment and maintenance approaches focused on MMX® mesalamine [PDF]
, 2012 Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that typically manifests as diarrhea, abdominal pain, and bloody stool. Complications, such as colorectal cancer and extraintestinal manifestations, may also develop.
Moss, Alan C., Nanda, Kavinderjit
core +1 more source
بررسی اثر 5- آمينوساليسيليک اسيد(5-ASA) در آسيب ناشی از ايسکمی و رپرفيوژن در کليه موش صحراييThe Assessment of 5-Aminosalicylic Acid(5-ASA) Effect on Ischemia-Reperfusion Injury of the Kidney in Rats [PDF]
, 2005 زمينه و هدف: انسداد شريان اندامها باعث ايسکمی میشود. رفع اين انسداد و برقراری مجدد جريان خون(رپرفيوژن) باعث ايجاد آسيب بيشتر بافتی میگردد که به نام آسيب ناشی از رپرفيوژن موسوم است.
بنائی گيوی, شکوفه +2 more
core
İstanbul Kuzey Klinikleri, 2018 INTRODUCTION[|]In this study,the effect of mesalazine was studied on TNF alpha IL-1 beta, IL-6, and C-reactive protein (CRP) levels and inflammatory changes in rat lungs with experimental peritonitis.[¤]METHODS[|]In total, 24 male Sprague–Dawley rats ...
Aziz Şener +4 more
doaj +1 more source
Case Reports in Cardiology, 2015 Mesalazine- (5-aminosalicylic acid-) containing products are a well-known treatment for inflammatory bowel disease, often as first line. Myocarditis is recognized as a very rare possible side effect of this drug treatment. We present a case of mesalazine-
Michele Sorleto +2 more
doaj +1 more source
Flavanol monomer-induced changes to the human faecal microflora [PDF]
, 2008 We have investigated the bacterial-dependent metabolism of ( − )-epicatechin and (+)-catechin using a pH-controlled, stirred, batch-culture fermentation system reflective of the distal region of the human large intestine.
Xenofon Tzounis +13 more
core +1 more source
Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps
Mediators of Inflammation, 2013 Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases. Since NET-formation in response to several biological and chemical stimuli is mostly ROS dependent, in theory any substance that ...
Tina Kirchner +6 more
doaj +1 more source
Journal of Acute Disease, 2013 Objective: To study magnetic microspheres of mesalamine (5-aminosalicylic acid) for colon drug delivery. Methods: Magnetic microspheres were prepared by solvent evaporation technique for use in the application of magnetic carrier technology.
Satinder Kakar +2 more
doaj +1 more source
Regulation of Cardiomyocyte Proliferation by microRNAs and Small Molecules [PDF]
, 2018 Understanding the molecular mechanisms regulating cardiac cell proliferation during the embryonic, fetal and adult life holds a paramount importance in view of developing innovative strategies aimed at inducing myocardial regeneration after cardiac ...
Torrini, Consuelo
core +1 more source
Efficacy of mesalazine at ulcerative colitis with nutritional failure
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2015 Aim of investigation. To specify relation between trophological status, severity of relapse of ulcerative colitis (UC) and efficacy of 5-aminosalicylic acid (5-ASA) for achievement of clinical remission.Summary.
A. V. Korolyov +4 more
doaj