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Mesalamine-Induced Myocarditis [PDF]

Cardiology Research and Practice, 2010
Nowadays mesalamine is a common treatment for Crohn's disease and hypersensitive reactions to this product have been reported. Yet there is limited information concerning mesalamine-induced myocarditis and its mechanism is not known.
Olivier Merceron, Clement Bailly, Antoine Khalil, Florence Pontnau, Nadjib Hammoudi, Richard Dorent, Pierre-Louis Michel   +6 more
doaj   +4 more sources

Real-World Adherence and Relapse Risk in Mesalamine Treatment for Ulcerative Colitis: Insights from a Large Japanese Medical Claims Database [PDF]

Inflammatory Intestinal Diseases
Introduction: 5-Aminosalicylic acid (5-ASA, mesalamine) is the cornerstone for maintaining remission in mild-to-moderate ulcerative colitis (UC), with several formulations available.
Takafumi Wada, Shuhei Hosomi, Yumie Kobayashi, Rieko Nakata, Yu Nishida, Hirotsugu Maruyama, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Fumio Tanaka, Yasuhiro Fujiwara   +11 more
doaj   +2 more sources

Gut Microbiota and Related Metabolites Were Disturbed in Ulcerative Colitis and Partly Restored After Mesalamine Treatment

Frontiers in Pharmacology, 2021
Mesalamine has been well used in the improvement of ulcerative colitis (UC) in clinics, however, the underlying mechanisms were not well illustrated. To explore its efficacy from the perspective of gut microbiota and related metabolites, we employed 16S ...
Dang Yanqi, Guang Ji, Liang Dai
exaly   +3 more sources

Significance of the drug-induced lymphocyte stimulation test for various oral mesalamines in ulcerative colitis with mesalamine intolerance. [PDF]

PLoS ONE
This study aimed to determine if the drug-induced lymphocyte stimulation test (DLST) for various oral mesalamines can diagnose mesalamine intolerance and predict the success of retreatment in patients with adverse events (AEs) due to the first oral 5 ...
Akira Madarame, Masakatsu Fukuzawa, Kumiko Uchida, Tadashi Ichimiya, Sakiko Naito, Yoshiya Yamauchi, Takashi Morise, Yasuyuki Kagawa, Takahiro Muramatsu, Takao Itoi   +9 more
doaj   +2 more sources

Recurrent pleuropericarditis associated with mesalazine therapy masked by steroid use [PDF]

European Journal of Case Reports in Internal Medicine
Introduction: Mesalazine is a cornerstone therapy for ulcerative colitis (UC). Although generally safe, it can cause rare but life-threatening cardiopulmonary complications such as pleuropericarditis.
Hakan Demiröz, Hasan Eruzun, Handan Doğan Çakmak, Aydın Can Ulusoy, Yusuf Bünyamin Ketenci, Mehmet Akca, Ahmet Bektaş   +6 more
doaj   +2 more sources

Translational Modeling of Gut Microbiome‐Mediated Drug Metabolism: A Case Example of Sulfasalazine [PDF]

CPT: Pharmacometrics & Systems Pharmacology
The gut microbiome can contribute to drug metabolism and significantly influence pharmacokinetic (PK) behavior. Sulfasalazine is well‐known to be metabolized by gut bacterial azoreductases into sulfapyridine and mesalamine.
Lisa Cheng, Jingwei Cai, Alexis Auster, Sungjoon Cho, Mary Keir, Horace Rhee, Bennett Kapili, Dari Shalon, Miaoran Ning   +8 more
doaj   +2 more sources

Adjunctive Pentoxifylline Enhances Clinical Remission and Reduces Inflammatory Biomarkers in Mild-to-Moderate Ulcerative Colitis: A Randomized Double-Blind Placebo-Controlled Pilot Trial [PDF]

Pharmaceuticals
Background: Despite mesalamine’s efficacy in mild-to-moderate ulcerative colitis (UC), many patients fail to achieve complete clinical or biochemical remission.
Mohannad O. Khrieba, Furqan M. Abdulelah, Amal Mohammed Badawoud, Eman Hamza, Reham A. Al-Dhelaan, Tarek I. Ahmed, Ahmed G. Abdelhameed, Nora Elshorbagi, Doaa A. El-Hanafy, Nashwa Eltantawy, Muhammed M. Salahuddin, Noha M. Elkhodary, Kholoud H. Radwan, Khaled Abo Bakr Khalaf Ali, Abeer A. El-Sayed, Marwa Kamal   +15 more
doaj   +2 more sources

Proteomic profile of human colon organoids: effects of a multi-mineral intervention alone and in the presence of pro-inflammatory and anti-inflammatory treatments [PDF]

Frontiers in Gastroenterology
IntroductionAquamin, a multi-mineral product derived from fossilized red marine algae, has been shown to improve colon barrier structure and function.
Muhammad Nadeem Aslam, Shannon D. McClintock, Gillian Moraga, Daniyal M. Nadeem, Isabelle Harber, James Varani   +5 more
doaj   +2 more sources

Mesalamine induced eosinophilic pneumonia

Respiratory Medicine Case Reports, 2017
We present the case of a twenty two year old Caucasian male with ulcerative colitis on mesalamine who presented with dry cough, fever, malaise and dyspnea on exertion.
Ankit Gupta, MD, MS, Swati Gulati, MD, MS   +1 more
doaj   +3 more sources

Mesalamine-Induced Eosinophilic Pneumonia. [PDF]

Cureus
Eosinophilic pneumonia encompasses a group of lung disorders characterized by peripheral blood eosinophilia. While its etiology is often idiopathic or infectious, non-infectious causes, including drug-induced reactions, should also be considered. Common culprits of drug-induced eosinophilic pneumonia include daptomycin, phenytoin, and nitrofurantoin ...
Sharma M, Sotelo JE, Schultz S.
europepmc   +3 more sources