Results 41 to 50 of about 8,428 (249)

Anti-oxidant and anti-inflammatory potential of different polymer-based mesalamine delayed-release granules in TNBS-induced ulcerative colitis in wistar rats

Saudi Pharmaceutical Journal
Ulcerative colitis (UC) is an inflammatory condition of colon characterized by severe damage to the innermost colon tissues. A number of studies described the use of medication delivery systems based on natural polymers like polysaccharides for the ...
Imtiyaz Ahmed Najar, Archana Sharma, Abdulrahman Alshammari, Thamer H. Albekairi, Metab Alharbi, Taief Ahmad Dar, Zulfkar Latief Qadrie, Atul Kabra, A.M.J Newton, Manish Kumar   +9 more
doaj   +1 more source

Design and Characterization of Mesalamine Loaded Nanoparticles for Controlled Delivery System [PDF]

Nanomedicine Research Journal, 2016
Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects.
Simin Seifirad, Hasan Karami, Shadab Shahsavari, Farzad Mirabasi, Farid Dorkoosh   +4 more
doaj   +1 more source

The decline of 6‐thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease

British Journal of Clinical Pharmacology, EarlyView.
Background Thiopurines are used to maintain remission in inflammatory bowel disease (IBD). These drugs are metabolized into 6‐thioguanine nucleotides (6‐TGN), associated with efficacy, and 6‐methylmercaptopurine ribonucleotides (6‐MMPR), associated with adverse drug reactions. Pregnancy has been linked to a shift in thiopurine metabolism, characterized
Dianne G. Bouwknegt, Paola Mian, Femke Groen, Denise van den Berg‐Zuiddam, Andrea E. van der Meulen, Femke Crouwel, Nanne K. de Boer, Debbie S. Deben, Dennis R. Wong, Luc J. J. Derijks, Gerard Dijkstra, Arno R. Bourgonje, C. Janneke van der Woude, Marijn C. Visschedijk   +13 more
wiley   +1 more source

Mesalamine induced hepatotoxicity. Is mesalamine safe?

Revista Española de Enfermedades Digestivas
Mesalamine is a medication used widely in the treatment of patients with inflammatory bowel disease. Although mesalamine is considered safe, hepatotoxicity has been reported with an incidence of 0-4%. We present the clinical picture of a patient with hepatotoxicity due to mesalamine.
Javier, Pérez-Valenzuela, Lorena, Castro Solari, Rodrigo, Quera, Luis, Contreras   +3 more
openaire   +2 more sources

Impact of 5‐ASA discontinuation in children with ulcerative colitis on biologic therapy: A propensity score‐matched study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives 5‐Aminosalicylic acid (5‐ASA) is recommended as a first‐line medication in mild to moderate ulcerative colitis (UC), but indications regarding its use in children with moderate to severe disease treated with biologics are lacking.
Giulia D'Arcangelo, Luca Scarallo, Giulia Mancuso, Mara Corpino, Claudio Romano, Lorenzo Norsa, Serena Arrigo, Matteo Bramuzzo, Maria Teresa Fioretti, Giovanna Zuin, Maria Teresa Illiceto, Paolo Lionetti, Marina Aloi   +12 more
wiley   +1 more source

Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis : A Prospective Cohort Study [PDF]

, 2017
Background: Paediatric ulcerative colitis [UC] is more extensive than adult disease, and more often refractory to mesalamine. However, no prospective trials have evaluated mesalamine enemas for inducing remission in children. Our goal was to evaluate the
Shamaly, Hussein, Broide, Efrat, Kaija-Leena Kolho, Gili Focht, Oren Ledder, Kolho, Kaija-Leena, Focht, Gili, Michal Kori, Ron Shaoul, Shabat, Chen Sarbagili, Shaoul, Ron, Shlomi Cohen, Ebby Shachmon, Levine, Arie, Yerushalmi, Baruch, Ledder, Oren, Shteyer, Eyal, Turner, Dan, On, Avi, Eyal Shteyer, Hussein Shamaly, Shachmon, Ebby, Cohen, Shlomi, Kori, Michal, Efrat Broide, Boaz, Mona, Dan Turner, Avi On, Mozer-Glassberg, Yael, Yael Mozer-Glassberg, Arie Levine, Chen Sarbagili Shabat, Sarit Peleg, Mona Boaz, Peleg, Sarit, Baruch Yerushalmi   +35 more
core   +1 more source

Outcomes and adverse effects of teduglutide treatment with periodic withdrawal in pediatric short bowel patients

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives We evaluated the efficacy and safety of teduglutide in a real‐world cohort in which national reimbursement policies required treatment interruptions. The primary outcomes were reduction in parenteral support (PS) and treatment‐related adverse effects, and the secondary outcome was the impact of the mandated withdrawal periods ...
Riikka Gunnar, Annika Mutanen, Mikko P. Pakarinen, Laura Merras‐Salmio   +3 more
wiley   +1 more source

The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.

PLoS ONE, 2014
UnlabelledThe anti-inflammatory agent, mesalamine (5-aminosalicylic acid) has been shown to decrease mucosal inflammation in ulcerative colitis. The effect of mesalamine in HIV-infected individuals, who exhibit abnormal mucosal immune activation and ...
Ma Somsouk, Richard M Dunham, Michelle Cohen, Rebecca Albright, Mohamed Abdel-Mohsen, Teri Liegler, Jeffrey Lifson, Michael Piatak, Robert Gorelick, Yong Huang, Yuaner Wu, Priscilla Y Hsue, Jeffrey N Martin, Steven G Deeks, Joseph M McCune, Peter W Hunt   +15 more
doaj   +1 more source

Bowel ultrasound scan in the management of pediatric moderate ulcerative colitis: The applicability of international bowel ultrasound segmental activity score

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To evaluate bowel ultrasound (BUS) findings and the diagnostic and prognostic performance of international bowel ultrasound segmental activity score (IBUS‐SAS) in children with moderate ulcerative colitis (UC), including its accuracy for assessing endoscopic activity and predicting clinical remission and colectomy within 12 months ...
Martina Di Benedetto, Luca Scarallo, Camilla Pannacci, Sara Renzo, Monica Paci, Sara Naldini, Jacopo Barp, Laura Tasciotti, Paolo Lionetti   +8 more
wiley   +1 more source

Ocular facial myositis and sialadenitis presenting with new onset ulcerative colitis

JPGN Reports, EarlyView.
Abstract Extra‐intestinal manifestations of inflammatory bowel disease (IBD) can involve most organ systems, although the immunologic underpinnings are not well understood. Most patients who present with an extra‐intestinal manifestation have a single site of extra‐intestinal involvement; however, a small cohort presents with multiple different sites ...
Nicole Du, Nicole Mendez, Anil Darbari
wiley   +1 more source