Results 1 to 10 of about 7,176,980 (297)

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

Nature, 2012
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other populations.
Sebastian Zeissig, James Lee, Zhi Wei
exaly   +2 more sources

IL-12 and IL-23 pathway inhibition in inflammatory bowel disease

Nature Reviews Gastroenterology and Hepatology, 2023
IL-12 and IL-23 have been implicated in inflammatory bowel disease. In this Review, Vande Casteele and colleagues summarize the mechanistic role of IL-12 and IL-23 in inflammatory bowel disease, and discuss the clinical development of drugs targeting IL ...
Bruce E. Sands, Clara Abraham, William A Faubion   +2 more
exaly   +2 more sources

Microbial genes and pathways in inflammatory bowel disease

Nature Reviews Microbiology, 2019
Perturbations in the intestinal microbiome are implicated in inflammatory bowel disease (IBD). Studies of treatment-naive patients have identified microbial taxa associated with disease course and treatment efficacy.
Melanie Schirmer, Ramnik J Xavier, Hera Vlamakis   +2 more
exaly   +2 more sources

Novel Utility of Leucine-Rich Alpha-2-Glycoprotein as a Biomarker in Ulcerative Colitis: A Predictor of Endoscopic Remission Independent of Symptoms

Inflammatory Intestinal Diseases, 2023
Introduction: Leucine-rich alpha-2-glycoprotein (LRG) is a potential biomarker for disease activity and reflects mucosal healing in patients with ulcerative colitis (UC).
Tomoyuki Hayashi, Kazuya Kitamura, Masaaki Usami, Masaki Miyazawa, Masaki Nishitani, Akihiro Dejima, Makoto Yamamoto, Shotaro Kawase, Masaya Funaki, Noriaki Orita, Hidetoshi Nakagawa, Koki Morita, Noriho Iida, Akihiro Seki, Kouki Nio, Hidenori Kido, Hideo Takayama, Yuta Takeuchi, Shinya Yamada, Hajime Takatori, Mari Shimada, Hiroto Saito, Daisuke Yamamoto, Tadashi Toyama, Taro Yamashita   +24 more
doaj   +1 more source

Endoplasmic Reticulum Stress in Colonic Mucosa of Ulcerative Colitis Patients Is Mediated by PERK and IRE1 Pathway Activation

Mediators of Inflammation, 2022
Ulcerative colitis (UC) is characterized by a chronic overproduction of proinflammatory cytokines. During an acute phase, the endoplasmic reticulum (ER) is overloaded and the protein folding process is impaired, a condition named ER stress.
Bruno Lima Rodrigues, Isabella Dotti, Lívia Bitencourt Pascoal, Joseane Morari, Miriam Esteller, Andressa Coope, Maria de Lourdes Setsuko Ayrizono, Azucena Salas, Raquel Franco Leal   +8 more
doaj   +1 more source

Impact of the body mass index on the retention of the anorectal mucosa after double-stapled ileal pouch-anal anastomosis for ulcerative colitis

BMC Gastroenterology, 2023
Background Double-stapled ileal pouch-anal anastomosis (DS-IPAA) is easy to construct and has a good functional outcome in patients with ulcerative colitis (UC). However, retention of the anorectal mucosa may lead to a subsequent risk of inflammation and
Hideaki Kimura, Kenichiro Toritani, Reiko Kunisaki, Kenji Tatsumi, Kazutaka Koganei, Akira Sugita, Itaru Endo   +6 more
doaj   +1 more source

ESPEN guideline on Clinical Nutrition in inflammatory bowel disease.

Clinical Nutrition, 2023
The present guideline is an update and extension of the ESPEN scientific guideline on Clinical Nutrition in Inflammatory Bowel Disease published first in 2017.
S. Bischoff, P. Bager, J. Escher, A. Forbes, X. Hébuterne, C. Hvas, F. Joly, S. Klek, Ž. Krznarić, J. Ockenga, S. Schneider, R. Shamir, K. Stardelova, D. Bender, N. Wierdsma, Arved Weimann   +15 more
semanticscholar   +1 more source

STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

Gastroenterology, 2020
BACKGROUND The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients.
D. Turner, A. Ricciuto, Ayanna E. Lewis, F. D'Amico, J. Dhaliwal, A. Griffiths, D. Bettenworth, W. Sandborn, B. Sands, W. Reinisch, J. Schölmerich, W. Bemelman, S. Danese, J. Mary, D. Rubin, J. Colombel, L. Peyrin-Biroulet, I. Dotan, M. Abreu, A. Dignass   +19 more
semanticscholar   +1 more source

Clinicopathological and prognostic evaluations of anorectal cancer after fecal diversion for patients with Crohn’s disease

BMC Gastroenterology, 2021
Purpose Colorectum diversion with a proximal stoma is often the preferred surgical approach in patients with Crohn's disease-related anorectal lesions or refractory colitis.
Hirosuke Kuroki, Akira Sugita, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Eiichi Nakao, Nao Obara, Katsuhiko Arai   +7 more
doaj   +1 more source

Clinical features and surgical selection in colitis-associated colorectal cancer with ulcerative colitis

BMC Surgery, 2023
Purpose The aim of this study was to compare the clinical characteristics of ulcerative colitis (UC) patients who underwent surgery for cancer/dysplasia with those who underwent surgery for refractory disease and to discuss the preoperative preparation ...
Ryuichi Kuwahara, Hiroki Ikeuchi, Kurando Kusunoki, Tomohiro Minagawa, Yuki Horio, Kei Kimura, Kozo Kataoka, Naohito Beppu, Masataka Ikeda, Motoi Uchino   +9 more
doaj   +1 more source