Results 141 to 150 of about 49,029 (222)

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang   +16 more
wiley   +1 more source

MRI Epicenters Differentiate Spatiotemporal Patterns of Neurodegeneration in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
A connectivity‐based MRI epicenter model identifies two Parkinson's disease subtypes: subtype 1 with infratentorial‐dominant epicenters, severe motor symptoms, and rapid progression; and subtype 2 with supratentorial‐dominant epicenters with mild progression.
Xiaojie Duanmu   +23 more
wiley   +1 more source

Analysing gender disparities in youth sports coaching: an international survey (FEMCoach project). [PDF]

open access: yesFront Psychol
Dias V   +9 more
europepmc   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

open access: yesAdvanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li   +10 more
wiley   +1 more source

King and Cochrane: The technological treadmill and racial inequity in US agriculture

open access: yesApplied Economic Perspectives and Policy, EarlyView.
Abstract Between 1920 and 1969, the number of Black farmers in the US decreased from 14% of all operators to 4%. Using Martin Luther King Jr.'s critique of agricultural policy and Willard Cochrane's theory of the technological treadmill, we explore how racial discrimination was linked to policies that led to structural change in US agriculture.
Jared Hutchins, Jacopo De Marinis
wiley   +1 more source

Do Consumers Value Diversity in Agriculture? A Choice Experiment

open access: yesApplied Economic Perspectives and Policy, EarlyView.
ABSTRACT Farm ownership in the US today is racially and ethnically homogeneous. Diverse farmers and ranchers make up less than 10% of all producers, they tend to be less financially stable and have tighter profit margins. In the past few years, both government and industry programs have aimed to increase the participation and profitability of diverse ...
Maria Kalaitzandonakes   +2 more
wiley   +1 more source

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