Results 201 to 210 of about 669,118 (323)

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

open access: yesAdvanced Science, EarlyView.
Alzheimer's disease (AD) is the most common neurodegenerative disorder. This study demonstrates that microglial Rack1 deficiency decreased Aβ deposition and neuroinflammation and ameliorated cognitive impairments in AD model mice by enhancing IGF1‐mediated astrocytic phagocytosis.
Jingdan Zhang   +13 more
wiley   +1 more source

Correction: MANdatory - why men need (and are needed for) gender equality progress. [PDF]

open access: yesFront Psychol
Van Laar C   +4 more
europepmc   +1 more source

12‐HETE Is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

open access: yesAdvanced Science, EarlyView.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li   +13 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

open access: yesAdvanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang   +7 more
wiley   +1 more source

Efficiency Recalibrates Social‐Emotional Trade‐Offs Behind Partner Choice in Direct Reciprocity through Intention‐Specific Neural Bases

open access: yesAdvanced Science, EarlyView.
Bridging the gap between two crucial mechanisms of cooperation, namely direct reciprocity and partner choice, this study reveals the neurocognitive bases underlying how individuals prioritize reciprocal partner when receiving help from multiple benefactors with diverse intentions and reciprocal efficiency. The efficiency‐driven reciprocal decisions are
Rui Liao   +5 more
wiley   +1 more source

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