β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio+11 more
wiley +1 more source
Safety and efficacy of a feed additive consisting of a tincture derived from the leaves of <i>Ocimum basilicum</i> L. (basil tincture) for use in all animal species (FEFANA asbl). [PDF]
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)+23 more
europepmc +1 more source
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez+8 more
wiley +1 more source
Image dataset of Taro Leaf Blight disease collected from the West African Sub-Region. [PDF]
Nwaneto C+4 more
europepmc +1 more source
Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang+13 more
wiley +1 more source
Taurine Mitigates Metaflumizone-Induced Hepatonephrotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation, and Apoptosis. [PDF]
Demirel HH+4 more
europepmc +1 more source
RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav+5 more
wiley +1 more source
Acaricidal Efficacy of Diatomaceous Earths on Different Life Stages of <i>Acarus siro</i> L. and <i>Tyrophagus putrescentiae</i> (Schrank). [PDF]
Boukouvala MC+2 more
europepmc +1 more source