Results 41 to 50 of about 2,743,271 (265)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Deriva e Suas Pistas Dentro de um Processo de Criação Cênica Pelo Mar de Ruas e Praças
Pitágoras 500, 2016 Este artigo relata as experiências da Trupé de Teatro em processo colaborativo de criação cênica pelas ruas e praças do Centro da cidade de Sorocaba. Buscamos, aqui, pistas sobre a Deriva, o estado de Deriva - procedimento utilizado pelo grupo durante a ...
Carlos Alberto Doles Junior +1 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Pitágoras 500, 2019 Neste artigo, analisaremos os métodos de trabalho e os espetáculos selecionados do diretor polonês Tadeusz Kantor e do diretor brasileiro Antunes Filho.
Argus Cecil Nery Monteiro
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Pitágoras 500, 2012 A representação do negro no teatro brasileiro, quase sempre, foi influenciada pela ideia de que os negros não enfrentavam problemas que impedissem seu amplo desenvolvimento espiritual, fisíco e material, supunha-se, assim, que viviam numa espécie de ...
Christian Fernando dos Santos Moura
doaj +3 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Pitágoras 500, 2020 O presente texto é uma transcrição da palestra realizada por Pedro García Blanco em 17 de novembro de 2020. Esta palestra fez parte do ciclo IA Convida, promovido pelo Instituto de Artes da UNICAMP dentro do projeto Renovagrad.
Pedro García Blanco
doaj +1 more source