Results 51 to 60 of about 2,743,271 (265)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
O Teatro do Cotidiano: epicidade e dramaticidade em A Procura de Emprego de Michel Vinaver
Pitágoras 500, 2015 O ensaio examina na peça À Procura de Emprego de Mi- chel Vinaver os desdobramentos épicos e dramáticos no desenvol- vimento de seus temas. Partindo dos estudos de Jean Pierre Sarra- zac, procurou-se examinar aí uma poética de cunho intimista em torno de
Isa Etel Kopelman, Bruna Luiza Munhoz
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Máquinas desumanizadoras, máquinas humanizadoras: sobre o teatro e a tecnologia
Pitágoras 500, 2012 Departing from the analysis of three theatre plays: A voz humana [La Voix Humaine] by Jean Cocteau, The Gigli concert by Thomas Murphy and Krapp’s last tape by Samuel Beckett, it is intended to question how the contemporary relations between man and ...
Eunice Gonçalves Duarte
doaj
Pitágoras 500, 2011 Este artigo ilustra algumas leituras de textos dramáticos clássicos e as distintas possibilidades de sua performação.
Isa Etel Kopelman
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
As mãos literárias e a influência no teatro: Hamlet e O marinheiro
Pitágoras 500, 2014 Propomo-nos evidenciar como a mão literária de Fernando Pessoa, pousada sobre a mão literária de Shakespeare, seu precursor, pressionando-a, potencializa as impossibilidades de sentido da linguagem.
Juliana Elesbão, Eduardo da Luz
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Pitágoras 500, 2014 Em fins de 1897, encena-se Amor ao pelo, paródia do drama de Coelho Netto Pelo Amor!. Por detrás da alcunha de *** que a assina, mal se esconde Arthur Azevedo, teatrólogo cuja preferência pelo teatro popular Netto criticara sistematicamente, enquanto ...
Danielle Crepaldi Carvalho
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source