Results 81 to 90 of about 9,896,464 (337)

Excess entropy and energy feedback from within cluster cores up to r$_{200}$ [PDF]

open access: yes, 2017
We estimate the "non-gravitational" entropy-injection profiles, $\Delta K$, and the resultant energy feedback profiles, $\Delta E$, of the intracluster medium for 17 clusters using their Planck SZ and ROSAT X-Ray observations, spanning a large radial ...
Eckert, Dominique   +5 more
core   +2 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

As mãos literárias e a influência no teatro: Hamlet e O marinheiro

open access: yesPitágoras 500, 2014
Propomo-nos evidenciar como a mão literária de Fernando Pessoa, pousada sobre a mão literária de Shakespeare, seu precursor, pressionando-a, potencializa as impossibilidades de sentido da linguagem.
Juliana Elesbão, Eduardo da Luz
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Um cômico na Academia: o lugar da paródia Amor ao pelo, de Arthur Azevedo, na cena artística carioca de 1897

open access: yesPitágoras 500, 2014
Em fins de 1897, encena-se Amor ao pelo, paródia do drama de Coelho Netto Pelo Amor!. Por detrás da alcunha de *** que a assina, mal se esconde Arthur Azevedo, teatrólogo cuja preferência pelo teatro popular Netto criticara sistematicamente, enquanto ...
Danielle Crepaldi Carvalho
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

A brutal solidão negra no paraíso racial: a representação do negro no teatro brasileiro moderno a partir da leitura da peça Anjo negro, de Nelson Rodrigues

open access: yesPitágoras 500, 2012
A representação do negro no teatro brasileiro, quase sempre, foi influenciada pela ideia de que os negros não enfrentavam problemas que impedissem seu amplo desenvolvimento espiritual, fisíco e material, supunha-se, assim, que viviam numa espécie de ...
Christian Fernando dos Santos Moura
doaj   +1 more source

Secure Directories [PDF]

open access: yes, 2000
This paper describes the mechanisms that are needed in order to provide a secure directory service based on the X.500 data model. A brief introduction to the X.500 data model is given followed by an overview of the Lightweight Directory Access Protocol ...
Chadwick, David W.
core  

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

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