Results 81 to 90 of about 9,918,450 (306)
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Important Lessons Derived from X.500 Case Studies [PDF]
, 1996 X.500 is a new and complex electronic directory technology, whose basic specification was first published as an international standard in 1988, with an enhanced revision in 1993. The technology is still unproven in many organisations. This paper presents
Chadwick, David W.
core
CARMA observations of massive Planck-discovered cluster candidates at z>0.5 associated with WISE overdensities: Breaking the size-flux degeneracy [PDF]
, 2015 We use a Bayesian software package to analyze CARMA-8 data towards 19 unconfirmed Planck SZ-cluster candidates from Rodriguez-Gonzalvez et al. (2015), that are associated with significant overdensities in WISE.
Chary, R. +6 more
core +5 more sources
Pitágoras 500, 2012 This article intends to, besides pointing how important is improvisation to the creative process of an actor, show that is through improvisation that the actor finds an infinite source to turn his actions into art. This article discusses the problem of a
Marcelo Lazzaratto
doaj
Ação e imagin(ação) em A falecida de Nelson Rodrigues
Pitágoras 500, 2012 O presente artigo tem por objetivo analisar as formas teatrais da peça A falecida, de Nelson Rodrigues. Na peça, há uma criação ficcional que foge à intencionalidade clássica do teatro, a ação, e se constitui como responsável pelo conflito da obra ...
Thais Carvalho Fonseca +1 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
A imitação do corpo no Auto da barca do inferno
Pitágoras 500, 2011 Malgré la problématique historico-littéraire qui implique les origines du théâtre vicentin, ainsi que sa filiation à une présomption théâtrale allégorique et de caractère théologique et moral, cette étude vise à trouver dans le texte de l'acte de la ...
Jaqueson Luiz da Silva
doaj
Orestes entre o ontem e o hoje: propostas para a leitura do mito
Pitágoras 500, 2013 Este artigo tem por objetivo analisar a tragédia grega Orestes, escrita por Eurípides e representada nas Dionísias Urbanas de 408 a.C. A peça trata da purgação do assassinato de Clitemnestra pelo filho Orestes, com a ajuda da irmã Electra e do amigo ...
Carlos Junior Gontijo Rosa
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source