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Adjustment for Inconsistency in Adaptive Phase 2/3 Designs With Dose Optimization. [PDF]

open access: yesPharm Stat
ABSTRACT Adaptive Phase 2/3 designs hold great promise in contemporary oncology drug development, especially when limited data from Phase 1 dose‐finding is insufficient for identifying an optimal dose. However, inconsistent results between Phase 2 and Phase 3 may raise regulatory and practical concerns.
Chen C, Huang M, Zhang X.
europepmc   +2 more sources

HIV-related knowledge and perceptions by academic major: Implications for university interventions

open access: yesFrontiers in Public Health, 2014
Most universities offer human sexuality courses, although they are not required for graduation. While students in health-related majors may receive sexuality education in formal settings, majority of college students never receive formal sexual health ...
Matthew Lee Smith   +4 more
doaj   +2 more sources

Update on (2+1+1)-flavor QCD equation of state [PDF]

open access: yesProceedings of The 38th International Symposium on Lattice Field Theory — PoS(LATTICE2021), 2021
Johannes Heinrich Weber,a,∗ Alexei Bazavov and Peter Petreczky Institut für Physik & IRIS Adlershof; Humboldt-Universität zu Berlin, Zum Großen Windkanal 6, D-12489 Berlin, Germany Department of Computational Mathematics, Science and Engineering ...
J. Weber, A. Bazavov, P. Petreczky
semanticscholar   +1 more source

Dynamic Time Warping Algorithm in Modeling Systemic Risk in the European Insurance Sector

open access: yesEntropy, 2021
We are looking for tools to identify, model, and measure systemic risk in the insurance sector. To this aim, we investigated the possibilities of using the Dynamic Time Warping (DTW) algorithm in two ways.
Anna Denkowska, Stanisław Wanat
doaj   +1 more source

A Locally Both Leptokurtic and Fat-Tailed Distribution with Application in a Bayesian Stochastic Volatility Model

open access: yesEntropy, 2021
In the paper, we begin with introducing a novel scale mixture of normal distribution such that its leptokurticity and fat-tailedness are only local, with this “locality” being separately controlled by two censoring parameters.
Łukasz Lenart   +2 more
doaj   +1 more source

SB-neutrosophic structures in BCK/BCI-algebras [PDF]

open access: yesJournal of Hyperstructures, 2023
This article presents the novel set termed SB - neutro-sophic set (SB-NSS), which extends the concept of the Neutrosophic set (NSS). We illustrate its fundamental operations with examples.This concept of SB-NSSs is appliedto BCK/BCI-algebras, and we ...
Bavanari Satyanarayana   +2 more
doaj   +1 more source

New Estimators of the Bayes Factor for Models with High-Dimensional Parameter and/or Latent Variable Spaces

open access: yesEntropy, 2021
Formal Bayesian comparison of two competing models, based on the posterior odds ratio, amounts to estimation of the Bayes factor, which is equal to the ratio of respective two marginal data density values.
Anna Pajor
doaj   +1 more source

Optimal consumption problem in the Vasicek model [PDF]

open access: yesOpuscula Mathematica, 2015
We consider the problem of an optimal consumption strategy on the infinite time horizon based on the hyperbolic absolute risk aversion utility when the interest rate is an Ornstein-Uhlenbeck process.
Jakub Trybuła
doaj   +1 more source

Can Producers’ Price War End Up in an Optimal Allocation?

open access: yesMathematics, 2022
The paper presents a theoretical framework for the phenomenon of the price war in the context of general equilibrium, with special attention to the production system.
Marta Kornafel
doaj   +1 more source

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