Results 11 to 20 of about 1,823,738 (182)

Discovery of a covalent inhibitor of KRASG12C (AMG 510) for the treatment of solid tumors.

Journal of Medicinal Chemistry, 2019
KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-"undruggable" target, however clinically viable inhibitors have ...
B. Lanman, Jennifer R. Allen, J. Allen, A. Amegadzie, K. Ashton, S. Booker, J. Chen, N. Chen, M. Frohn, G. Goodman, D. J. Kopecky, Longbin Liu, Patricia Lopez, J. D. Low, V. Ma, A. Minatti, Thomas T. Nguyen, N. Nishimura, Alexander J. Pickrell, Anthony B. Reed, Y. Shin, Aaron C. Siegmund, N. Tamayo, C. Tegley, Mary C. Walton, Hui-Ling Wang, Ryan P. Wurz, May Xue, Kevin C Yang, Pragathi Achanta, M. Bartberger, J. Canon, L. Hollis, J. McCarter, C. Mohr, K. Rex, A. Y. Saiki, Tisha San Miguel, Laurie P. Volak, Kevin H. Wang, D. Whittington, S. Zech, J. Lipford, V. Cee   +43 more
semanticscholar   +1 more source

A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture [PDF]

, 2012
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds are normally tested using static cell cultures but applied directly to tissue cultures in perfusion bioreactors.
Anderson, Britland, Casey, Chen, Clark, Csaderova, Curtis, Curtis, Flemming, Gadegaard, Gadegaard, Gailit, Hubbell, Jelinek, Korin, Lakatos, Link, Lu, Massia, Mirastschijski, Mosmann, Noble, Robert, Salem, Seunarine, Stevens, Sun, Sun, Sørensen, Terai, Wojciak-Stothard, Zong   +31 more
core   +2 more sources

Simultaneous Biatrial High-Density (510–512 Electrodes) Epicardial Mapping of Persistent and Long-Standing Persistent Atrial Fibrillation in Patients

Circulation, 2015
Seungyup Lee, Jayakumar Sahadevan, Celeen M. Khrestian, Ivan Cakulev, Alan Markowitz, Albert L. Waldo   +5 more
openalex   +2 more sources

KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations

Scientific Reports, 2020
The first KRAS(G12C) targeting inhibitor in clinical development, AMG 510, has shown promising antitumor activity in clinical trials. On the molecular level, however, the interaction dynamics of this covalently bound drug–protein complex has been ...
Tatu Pantsar
semanticscholar   +1 more source

Study of Influence of Calcium Content in Milk on Quality Indicators of Cottage Cheese [PDF]

, 2017
The analysis was realized, and the dependence between the calcium content and organoleptic and functional-technological properties of milk as a raw material for producing sour milk cheese was determined.
Grynchenko, N. (Nataliya), Pyvovarov, P. (Pavlo), Tyutyukova, D. (Daria)   +2 more
core   +2 more sources

Effect of Plant Growth-Promoting Rhizobacteria on Salicornia ramosissima Seed Germination under Salinity, CO2 and Temperature Stress [PDF]

, 2019
In a scenario of climate change and growing population, halophyte root microbiota interactions may be a sustainable solution to improve alternative crop production while combating abiotic stress.
Bernabeu Meana, Miguel, Mateos Naranjo, Enrique, Mesa Marín, Jennifer, Pajuelo Domínguez, Eloísa, Pérez Romero, Jesús Alberto, Redondo Gómez, Susana, Rodríguez Llorente, Ignacio David   +6 more
core   +1 more source

Beyond the 510(k): The regulation of novel moderate-risk medical devices, intellectual property considerations, and innovation incentives in the FDA’s De Novo pathway

npj Digit. Medicine
Moderate-risk medical devices constitute 99% of those that have been regulated by the U.S. Food and Drug Administration (FDA) since it gained authority to regulate medical technology nearly five decades ago.
M. Aboy, C. Crespo, A. Stern
semanticscholar   +1 more source

LncRNA MIR4435-2HG inhibits the progression of osteoarthritis through miR-510-3p sponging

Experimental and Therapeutic Medicine, 2020
Osteoarthritis (OA) is a disorder of diarthrodial joints that can have multiple causes. Long non-coding RNAs (lncRNAs) participate in multiple diseases, including OA.
Yingli Liu, Yun Yang, L. Ding, Yuqin Jia, Yun Ji   +4 more
semanticscholar   +1 more source

Photoproduction of \eta mesons on protons in the resonance region:The background problem and the third S_11 resonance

, 2003
We have constructed an isobar model for the $\eta$-photoproduction on the proton in the energy region up to the photon lab energy $K_0 = 3$ GeV. The data base involved into the fitting procedure includes precise results for the cross section and for the $
510, 81, Ajaka, Benmerrouche, Benmerrouche, Bennhold, Chen, Chew, Chiang, Chiang, Collaboration, Dugger, Fix, Group, Heusch, Hicks, Krusche, Renard, Tiator, Tryasuchev, Tryasuchev, V. A. Tryasuchev, Vartapetyan   +22 more
core   +1 more source

Traceability and AOSD - From Requirements to Aspects [PDF]

, 2006
The traceability question is addressed through the development of a framework to go from requirements to aspects using the Design by Contract methodology.
Laney, Robin, Thomas, Pete, van der Linden, Janet   +2 more
core