Results 271 to 280 of about 1,768,342 (381)

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

open access: yesAdvanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu   +5 more
wiley   +1 more source

DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing

open access: yesAdvanced Science, EarlyView.
In this work, a DNA sequential logic circuit is constructed that combines reusability and autonomy for the first time, including SR (Set‐Reset)‐latches composed of NOR gates, SR‐latches composed of NAND gates, and D (Data)‐latches. After fully utilizing the characteristics of each latch, to counter, toxin and miRNA detection and intracellular dynamic ...
Tianci Xie   +7 more
wiley   +1 more source

Pulsed Laser Synthesis of Carbon Nanostructures from Organic Molecular Liquids: Structure, Kinetics and Photophysical Properties

open access: yesAdvanced Science, EarlyView.
The non‐focused nanosecond pulsed laser irradiation of aromatic liquids produces amorphous carbon nanodots (CNDs) or curved‐graphene quantum dots (c‐GQDs) by surface‐catalyzed 0‐order reactions under kinetic control. C hybridization partially changes from sp2 to sp3. O‐based groups passivate the surface.
Antonio Ribeiro‐González   +8 more
wiley   +1 more source

FBXO2 Alleviates Intervertebral Disc Degeneration via Dual Mechanisms: Activating PINK1‐Parkin Mitophagy and Ubiquitinating LCN2 to Suppress Ferroptosis

open access: yesAdvanced Science, EarlyView.
F‐box only protein 2 (FBXO2) combats intervertebral disc degeneration (IVDD) by coordinating dual protection. It activates PTEN‐induced putative kinase 1 (PINK1)‐Parkin mitophagy restoring mitochondrial function and targets lipocalin‐2 (LCN2) for degradation, suppressing ferroptosis.
Tongde Wu   +7 more
wiley   +1 more source

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