Results 41 to 50 of about 1,823,440 (329)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Liquefaction and chemical composition of walnut shells

Open Agriculture, 2022
The cultivation of walnut (Juglans regia L.) for the exploitation of the fruit has been increasingly recognized worldwide; therefore, it is important to valorize a large amount of biomass from walnut shells (WS), where liquefaction may play an important ...
Domingos Idalina, Ferreira José, Cruz-Lopes Luísa P., Esteves Bruno   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Designing identity of a new material: a new product design approach [PDF]

, 2009
The present research is a design practice-based research based on the industrial development of a new concrete. The research focuses on the development of the specific identity of a new material. The research is aimed at demonstrating that product design
Aoussat, Améziane, Bassereau, Jean-François, Bergeret, Lorraine   +2 more
core  

Comment on ''Phase Diagram of La$_{2-x}$Sr$_x$CuO$_4$ Probed in the Infrared: Imprints of Charge Stripe Excitations''

, 2003
Recently Lucarelli {\it et al.} have reported\cite{lucarelli} temperature-dependence of the in-plane optical reflectivity of La$_{2-x}$Sr$_x$CuO$_4$ over a wide doping range, focusing on the infrared peaks at 30 cm$^{-1}$ (for $x$=0.12), 250 cm$^{-1 ...
B. P. Gorshunov, D. N. Basov, D. van der Marel, S. Tajima, S. Uchida   +4 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Characterization of Corn (Zea mays) Leaf Powder and Its Adsorption Properties Regarding Cu(II) and Cd(II) from Aqueous Samples

BioResources, 2014
In this study, a green adsorbent made of corn leaf powder was applied in the removal of Cu(II) and Cd(II) from water samples. The material was characterized by Fourier transform infrared (FTIR) spectroscopy, which indicated the existence of amine (1375 ...
Adrielli C. P. Silva, Alexandre O. Jorgetto, Marcos H. P. Wondracek, Margarida J. Saeki, José F. Schneider, Valber A. Pedrosa, Marco A. U. Martines, Gustavo R. Castro   +7 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Super Formula for Soluble C-Type Lectin-Like Receptor 2 × D-Dimer in Patients With Acute Cerebral Infarction

Clinical and Applied Thrombosis/Hemostasis
Acute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations.
Toshitaka Kamon MD, Hideo Wada MD, PhD, Shotaro Horie MD, Tomoya Inaba MD, Karin Okamoto MD, Katsuya Shiraki MD, PhD, Yuhuko Ichikawa, Minoru Ezaki, Motomu Shimaoka MD, PhD, Akisato Nishigaki MD, Akihiro Shindo MD, PhD, Hideto Shimpo MD, PhD, Nobuo Ito MD   +12 more
doaj   +1 more source

Potentially Toxic Metal and Metalloid Fractionation Contamination in Sediments of Daya Bay, South China Sea [PDF]

Kemija u Industriji, 2015
The metal profiles in sediments of the Daya Bay (DYB) in China were established using sequential extraction protocols proposed by the European Community Bureau of Reference (BCR).
L. L. Cao, J. Yang, P. Wang, L. Wang, H. T. Tian, M. K. Zou, J. Xie   +6 more
doaj   +1 more source