Results 51 to 60 of about 1,823,440 (329)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Assessment of Project Manager’s Competence in the Context of Individual Competence Baseline

Education Sciences, 2020
This study’s aim is to determine the consistency of student opinions regarding the importance of individual skills in three areas—people, practice, and perspective—with expert assessment. The study group consisted of five-year students accredited by IPMA
Mariusz Sołtysik, Małgorzata Zakrzewska, Adam Sagan, Szymon Jarosz   +3 more
doaj   +1 more source

The Warped Galaxy ESO 510 G13 Lithograph [PDF]

, 2003
This lithograph is part of a series designed to bring the latest Hubble Space Telescope images into the classroom. In the educational activity, In Search of ...

core  

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Evaluating Homomorphic Encryption Schemes for Privacy and Security in Healthcare Data Management

Journal of Cybersecurity and Privacy
Ensuring data privacy and security in sensitive domains such as healthcare remains a critical challenge. Homomorphic Encryption (HE) offers a promising approach by enabling computations directly on encrypted data, but the diversity of available schemes ...
Henrique Jorge, Cristina Wanzeller, João Henriques   +2 more
doaj   +1 more source

Reinstating Employer Accountability by Protecting All Forms of Whistleblowing: ERISA Section 510 [PDF]

, 2014
In the United States, employers who have little formal accountability largely manage health and retirement benefits of the working class. Employers face an enormous amount of responsibility to properly manage and protect the health and retirement ...
Hemlani, Roshni
core   +1 more source

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Evaluation of phenolic compounds and antioxidant activity in some edible flowers

Open Agriculture, 2020
Recently, edible flowers (EF) have aroused increased interest because of their aesthetic properties as well as potential health benefits related to the occurrence of some bioactive compounds.
Gonçalves Fernando, Gonçalves João Carlos, Ferrão Ana Cristina, Correia Paula, Guiné Raquel P. F.   +4 more
doaj   +1 more source

Maritime pine land use environmental impact evolution in the context of life cycle assessment

Open Agriculture, 2022
Between 2005 and 2015, the forest area occupied by maritime pine trees in Continental Portugal decreased by about 10.6%, and the existing volume decreased by about 18.4% mainly due to fires and pests (e.g., nematode) that occurred during this period. The
Ferreira José, Esteves Bruno, Cruz-Lopes Luísa P., Domingos Idalina   +3 more
doaj   +1 more source

Intramolecular Down‐ and Up‐Conversion in Dimeric Tetracene Complexes Centered via Platinum(II) and Palladium(II)

Advanced Functional Materials, EarlyView.
Metal‐tetracene dimeric complexes are synthesized through the pyridyl coordination to either Pt(II) or Pd(II). Photophysical properties are systematically compared as a function of the metal using steady‐state and time‐resolved spectroscopy. The Pt(II) dimer exhibits efficient intramolecular singlet fission and subsequent intramolecular up‐conversion ...
Yifan Bo, Yuxuan Hou, Melchor Matabuena, Rik R. Tykwinski, Dirk M. Guldi   +4 more
wiley   +1 more source