Results 51 to 60 of about 1,554,548 (330)
AMG 510 First to Inhibit "Undruggable" KRAS.
Cancer Discovery, 2019 Amgen's novel small-molecule inhibitor AMG 510 has become the first drug to successfully target a KRAS mutation in patients, according to findings presented at the 2019 American Society of Clinical Oncology Annual Meeting.
semanticscholar +1 more source
Longitudinal double-spin asymmetry for inclusive jet and dijet production in $pp$ collisions at $\sqrt{s} = 510$ GeV [PDF]
, 2019 Author(s): Adam, J; Adamczyk, L; Adams, JR; Adkins, JK; Agakishiev, G; Aggarwal, MM; Ahammed, Z; Alekseev, I; Anderson, DM; Aoyama, R; Aparin, A; Arkhipkin, D; Aschenauer, EC; Ashraf, MU; Atetalla, F; Attri, A; Averichev, GS; Bairathi, V; Barish, K ...
S. Adam +344 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Clinical and Applied Thrombosis/HemostasisAcute cerebral infarction (ACI) includes atherosclerotic and cardiogenic ACI and involves a thrombotic state, requiring antithrombotic treatment. However, the thrombotic state in ACI cannot be evaluated using routine hemostatic examinations.
Toshitaka Kamon MD +12 more
doaj +1 more source
Liquefaction and chemical composition of walnut shells
Open Agriculture, 2022 The cultivation of walnut (Juglans regia L.) for the exploitation of the fruit has been increasingly recognized worldwide; therefore, it is important to valorize a large amount of biomass from walnut shells (WS), where liquefaction may play an important ...
Domingos Idalina +3 more
doaj +1 more source
The Warped Galaxy ESO 510 G13 Lithograph [PDF]
, 2003 This lithograph is part of a series designed to bring the latest Hubble Space Telescope images into the classroom. In the educational activity, In Search of ...
core
FEBS Open Bio, EarlyView.We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley +1 more source
Onset symptoms in 510 patients with Huntington's disease. [PDF]
Journal of Medical Genetics, 1993 The onset of Huntington's disease (HD) is preceded or accompanied by events and symptoms which contribute to the natural history of the disease. Data obtained from the first 510 completed 'Questionnaires for Affected Individuals', recorded by the National Huntington's Disease Research Roster (NHDRR) were analysed. The following features were evaluated:
G Napolitano +5 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source
Evaluation of phenolic compounds and antioxidant activity in some edible flowers
Open Agriculture, 2020 Recently, edible flowers (EF) have aroused increased interest because of their aesthetic properties as well as potential health benefits related to the occurrence of some bioactive compounds.
Gonçalves Fernando +4 more
doaj +1 more source