Results 41 to 50 of about 1,748,964 (382)

The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.

Cancer Research, 2018
: Although renal cell carcinoma (RCC) is the most malignant urologic cancer, its pathogenesis remains unclear, and effective treatments for advanced RCC are still lacking.
Meng Ding, Xiaolan Lu, Cheng Wang, Quan Zhao, Jingping Ge, Q. Xia, Junjun Wang, Ke Zen, Chen-Yu Zhang, Chunni Zhang   +9 more
semanticscholar   +1 more source

Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes

Biomolecules, 2022
In the adult mammalian heart, no data have yet shown the existence of cardiomyocyte-differentiable stem cells that can be used to practically repair the injured myocardium.
Mariko Omatsu-Kanbe, Ryo Fukunaga, Xinya Mi, Hiroshi Matsuura   +3 more
doaj   +1 more source

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes

Molecular Cancer Therapeutics, 2019
Arry-520 is an advanced drug candidate from the Eg5 inhibitor class undergoing clinical evaluation in patients with relapsed or refractory multiple myeloma.
R. Indorato, S. Talapatra, Fangzhu Lin, S. Haider, S. Mackay, F. Kozielski, D. Skoufias   +6 more
semanticscholar   +1 more source

Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

Clinical pharmacology in drug development, 2016
ARC‐520 Injection, an RNA interference drug for the treatment of hepatitis B that targets cccDNA‐derived viral mRNA transcripts with high specificity, effectively reduces the production of viral proteins and HBV DNA.
T. Schluep, J. Lickliter, J. Hamilton, D. Lewis, Ching‐lung Lai, J. Lau, S. Locarnini, R. Gish, B. Given   +8 more
semanticscholar   +1 more source

The Community Initiative LEADER I and the implementation and results of the Hungarian Pilot LEADER programme in rural development

Bulletin of Geography. Socio-Economic Series, 2013
The aim of this study is to present the basic methodological elements of the LEADER Community Initiative in rural development established in 1991 and its practical implementation in geography.
RuszkaiCDFMR Csaba, KovácsCDFMR Tibor
doaj   +1 more source

Magnetism in nanometer-thick magnetite [PDF]

, 2011
The oldest known magnetic material, magnetite, is of current interest for use in spintronics as a thin film. An open question is how thin can magnetite films be and still retain the robust ferrimagnetism required for many applications.
Andrea Locatelli, Arantzazu Mascaraque, Benito Santos, José F. Marco, Juan de la Figuera, Kevin F. McCarty, Matteo Monti, Miguel Angel Niño, Oscar Rodríguez de la Fuente, R. Cornell, Tevfik Onur Menteş   +10 more
core   +4 more sources

Reorganisation of Earth’s biogeochemical cycles briefly oxygenated the oceans 520 Myr ago

, 2017
doi: 10.7185/geochemlet.1724 The Phanerozoic radiation of bilaterian animals has been linked to oxygenation of Earth’s oceans, due to the oxygen demand of the evolving animal ecosystems.
T. Dahl, J. Connelly, Artem V. Kouchinsky, Benjamin C Gill, S. F. Månsson, M. Bizzarro   +5 more
semanticscholar   +1 more source

Influence of secondary phases during annealing on re-crystallization of CuInSe2 electrodeposited films [PDF]

, 2009
Electrodeposited CuInSe2 thin films are of potential importance, as light absorber material, in the next generation of photovoltaic cells as long as we can optimize their annealing process to obtain dense and highly crystalline films.
Gobeaut, A., Kerrec, O., Laffont-Dantras, Lydia, Parissi, L., Tarascon, Jean-Marie   +4 more
core   +4 more sources

The Value of Interleukin-6 among Several Inflammatory Markers as a Predictor of Respiratory Failure in COVID-19 Patients

Diagnostics, 2021
Patients with coronavirus disease 2019 (COVID-19) develop severe respiratory failure within a short period during the clinical course. It is essential to predict respiratory deterioration in the short term. We investigated the use of inflammatory markers
Mitsuhiro Fujino, Michiyo Ishii, Takuya Taniguchi, Hiroya Chiba, Masaki Kimata, Masahito Hitosugi   +5 more
doaj   +1 more source

2.3 Gbit/s underwater wireless optical communications using directly modulated 520 nm laser diode.

Optics Express, 2015
We experimentally demonstrate a record high-speed underwater wireless optical communication (UWOC) over 7 m distance using on-off keying non-return-to-zero (OOK-NRZ) modulation scheme.
H. Oubei, Changping Li, Ki-Hong Park, T. Ng, Mohamed-Slim Alouini, B. Ooi   +5 more
semanticscholar   +1 more source