Results 21 to 30 of about 2,616,477 (235)

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

open access: yesPharmaceutics, 2021
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential.
Sangho Cho   +5 more
doaj   +1 more source

(Table 1) Carbon content and petroleum potential at DSDP Hole 73-520

open access: yes, 1984
At the end of the Leg 73 cruise, at Site 520, a thick upper Miocene facies of laminated diatomite was discovered. It was hypothesized that the sediment was derived from nutrient-rich waters in a young Cenozoic anoxic basin in the open Atlantic Ocean near
Deroo, Gerard   +3 more
core   +1 more source

The Community Initiative LEADER I and the implementation and results of the Hungarian Pilot LEADER programme in rural development

open access: yesBulletin of Geography. Socio-Economic Series, 2013
The aim of this study is to present the basic methodological elements of the LEADER Community Initiative in rural development established in 1991 and its practical implementation in geography.
RuszkaiCDFMR Csaba, KovácsCDFMR Tibor
doaj   +1 more source

Atypically Shaped Cardiomyocytes (ACMs): The Identification, Characterization and New Insights into a Subpopulation of Cardiomyocytes

open access: yesBiomolecules, 2022
In the adult mammalian heart, no data have yet shown the existence of cardiomyocyte-differentiable stem cells that can be used to practically repair the injured myocardium.
Mariko Omatsu-Kanbe   +3 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Comprehensive Assessment of Arterial, Tissue, and Venous Collaterals for Evaluating the Infarct Growth Rate: The Multimodal Collateral Score

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Collaterals are crucial factors that influence the infarct growth rate (IGR). We aimed to determine whether a comprehensive multimodal collateral score (MCS), incorporating collateral assessment at the arterial, tissue, and venous levels, is associated with functional independence and provides incremental prognostic value over ...
Giorgio Busto   +12 more
wiley   +1 more source

Current Overview of Osteogenesis Imperfecta

open access: yesMedicina, 2021
Osteogenesis imperfecta (OI), or brittle bone disease, is a heterogeneous disorder characterised by bone fragility, multiple fractures, bone deformity, and short stature.
Mari Deguchi   +5 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou   +16 more
wiley   +1 more source

Soluble Guanylate Cyclase Redox State Under Hypoxia or Hypoxia/Reoxygenation in Isolated Monkey Coronary Arteries

open access: yesJournal of Pharmacological Sciences, 2014
.: Hypoxia or hypoxia/reoxygenation impairs nitric oxide (NO)-mediated relaxation through the increase in superoxide generation in monkey coronary arteries.
Masashi Tawa   +5 more
doaj   +1 more source

Patient Demography (n = 520).

open access: yes, 2013
Patient Demography (n = 520).
Irene Schmidtmann (431243)   +7 more
core   +1 more source

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