Results 51 to 60 of about 1,737,981 (331)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Matrix Biology Plus, 2021 There is a general consensus that collagen stability is largely maintained by Pro and its major hydroxylated form, 4-hydroxyproline (4Hyp). However, positional difference in their stabilizing effect at the Xaa or Yaa position of collagenous Gly-Xaa-Yaa ...
Yuki Taga +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source
PGCE (FE) Teacher Training Incentive Grant Wales 2008/09: Post Graduate Certificate of Education (Further Education) Teacher Training Incentive Grant in Wales 2008/09 - guidance notes [PDF]
, 2008 "Guidance for use by PGCE (FE) initial teacher training providers offering the one year full time course [i.e. Cardiff University, Glyndwr University and University of Wales, Newport] in administering, assessing eligibility and the methodology for ...
core
Applying MOG to lensing: Einstein rings, Abell 520 and the Bullet Cluster
, 2018 We investigate gravitational lensing in the context of the MOG modified theory of gravity. Using a formulation of the theory with no adjustable or fitted parameters, we present the MOG equations of motion for slow, nonrelativistic test particles and for ...
Moffat, J. W., Rahvar, S., Toth, V. T.
core +2 more sources
Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: the Mars500 mission [PDF]
, 2021 Giovanni Bacci +7 more
openalex +1 more source
Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster +11 more
wiley +1 more source
Size-dependent fine-structure splitting in self-organized InAs/GaAs quantum dots [PDF]
, 2005 A systematic variation of the exciton fine-structure splitting with quantum dot size in single InAs/GaAs quantum dots grown by metal-organic chemical vapor deposition is observed.
A. Schliwa +6 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To compare the effectiveness and safety of tenecteplase (TNK) versus alteplase (TPA) in patients with basilar artery occlusion prior to endovascular treatment (EVT). Methods In this retrospective multicenter study (BAO‐TNK), we analyzed consecutive BAO patients from 14 U.S.
Rahul R. Karamchandani +38 more
wiley +1 more source