Results 51 to 60 of about 1,720,739 (382)

The E2F1-miR-520/372/373-SPOP Axis Modulates Progression of Renal Carcinoma.

Cancer Research, 2018
: Although renal cell carcinoma (RCC) is the most malignant urologic cancer, its pathogenesis remains unclear, and effective treatments for advanced RCC are still lacking.
Meng Ding, Xiaolan Lu, Cheng Wang, Quan Zhao, Jingping Ge, Q. Xia, Junjun Wang, Ke Zen, Chen-Yu Zhang, Chunni Zhang   +9 more
semanticscholar   +1 more source

Safety, Tolerability, and Pharmacokinetics of ARC‐520 Injection, an RNA Interference‐Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers

Clinical pharmacology in drug development, 2016
ARC‐520 Injection, an RNA interference drug for the treatment of hepatitis B that targets cccDNA‐derived viral mRNA transcripts with high specificity, effectively reduces the production of viral proteins and HBV DNA.
T. Schluep, J. Lickliter, J. Hamilton, D. Lewis, Ching‐lung Lai, J. Lau, S. Locarnini, R. Gish, B. Given   +8 more
semanticscholar   +1 more source

Niclosamide and its derivative DK‐520 inhibit RANKL‐induced osteoclastogenesis

FEBS Open Bio, 2020
Niclosamide is a potent inhibitor of osteoclastogenesis and bone remodeling. DK‐520 is an acyl derivative of Niclosamide and significantly increased both the plasma concentration and the duration of exposure of Niclosamide when dosed orally.
Yurui Jiao, Chenglong Chen, Xijian Hu, Xu Feng, Zhenqi Shi, Jie Cao, Qing Li, Yikun Zhu   +7 more
doaj   +1 more source

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers

Pharmaceutics, 2021
Dapagliflozin (DAP), which improves glycemic control in patients with type 2 diabetes mellitus, has poor physical properties against heat and moisture, thus hindering its manufacturing potential.
Sangho Cho, Jeongwook Lee, Yongwon Yoo, Minyong Cho, Seil Sohn, Beom-Jin Lee   +5 more
doaj   +1 more source

The Community Initiative LEADER I and the implementation and results of the Hungarian Pilot LEADER programme in rural development

Bulletin of Geography. Socio-Economic Series, 2013
The aim of this study is to present the basic methodological elements of the LEADER Community Initiative in rural development established in 1991 and its practical implementation in geography.
RuszkaiCDFMR Csaba, KovácsCDFMR Tibor
doaj   +1 more source

Influence of secondary phases during annealing on re-crystallization of CuInSe2 electrodeposited films [PDF]

, 2009
Electrodeposited CuInSe2 thin films are of potential importance, as light absorber material, in the next generation of photovoltaic cells as long as we can optimize their annealing process to obtain dense and highly crystalline films.
Gobeaut, A., Kerrec, O., Laffont-Dantras, Lydia, Parissi, L., Tarascon, Jean-Marie   +4 more
core   +4 more sources

Reorganisation of Earth’s biogeochemical cycles briefly oxygenated the oceans 520 Myr ago

, 2017
doi: 10.7185/geochemlet.1724 The Phanerozoic radiation of bilaterian animals has been linked to oxygenation of Earth’s oceans, due to the oxygen demand of the evolving animal ecosystems.
T. Dahl, J. Connelly, Artem V. Kouchinsky, Benjamin C Gill, S. F. Månsson, M. Bizzarro   +5 more
semanticscholar   +1 more source

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5–Inhibitor Complexes

Molecular Cancer Therapeutics, 2019
Arry-520 is an advanced drug candidate from the Eg5 inhibitor class undergoing clinical evaluation in patients with relapsed or refractory multiple myeloma.
R. Indorato, S. Talapatra, Fangzhu Lin, S. Haider, S. Mackay, F. Kozielski, D. Skoufias   +6 more
semanticscholar   +1 more source

Magnetism in nanometer-thick magnetite [PDF]

, 2011
The oldest known magnetic material, magnetite, is of current interest for use in spintronics as a thin film. An open question is how thin can magnetite films be and still retain the robust ferrimagnetism required for many applications.
Andrea Locatelli, Arantzazu Mascaraque, Benito Santos, José F. Marco, Juan de la Figuera, Kevin F. McCarty, Matteo Monti, Miguel Angel Niño, Oscar Rodríguez de la Fuente, R. Cornell, Tevfik Onur Menteş   +10 more
core   +4 more sources

Current Overview of Osteogenesis Imperfecta

Medicina, 2021
Osteogenesis imperfecta (OI), or brittle bone disease, is a heterogeneous disorder characterised by bone fragility, multiple fractures, bone deformity, and short stature.
Mari Deguchi, Shunichiro Tsuji, Daisuke Katsura, Kyoko Kasahara, Fuminori Kimura, Takashi Murakami   +5 more
doaj   +1 more source