Results 11 to 20 of about 1,599,471 (325)

Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia

Journal of Hematology & Oncology, 2020
Background Acute myeloid leukemia (AML) is the most common type of adult leukemia. Several studies have demonstrated that oncogenesis in AML is enhanced by kinase signaling pathways such as Src family kinases (SFK) including Src and Lyn, spleen tyrosine ...
Ola A. Elgamal, Abeera Mehmood, Jae Yoon Jeon, Bridget Carmichael, Amy Lehman, Shelley J. Orwick, Jean Truxall, Virginia M. Goettl, Ronni Wasmuth, Minh Tran, Shaneice Mitchell, Rosa Lapalombella, Sudharshan Eathiraj, Brian Schwartz, Kimberly Stegmaier, Sharyn D. Baker, Erin Hertlein, John C. Byrd   +17 more
doaj   +2 more sources

AZP-531, an unacylated ghrelin analog, improves food-related behavior in patients with Prader-Willi syndrome: A randomized placebo-controlled trial. [PDF]

PLoS ONE, 2018
Prader-Willi syndrome (PWS) is characterized by early-onset hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) hormone with a relative deficit of Unacylated Ghrelin (UAG).
Soraya Allas, Assumpta Caixàs, Christine Poitou, Muriel Coupaye, Denise Thuilleaux, Françoise Lorenzini, Gwenaëlle Diene, Antonino Crinò, Frédéric Illouz, Graziano Grugni, Diane Potvin, Sarah Bocchini, Thomas Delale, Thierry Abribat, Maithé Tauber   +14 more
doaj   +2 more sources

A compact iodine-laser operating at 531 nm with stability at the 10$^{-12}$ level and using a coin-sized laser module [PDF]

Optics Express, 2015
We demonstrate a compact iodine-stabilized laser operating at 531 nm using a coin-sized light source consisting of a 1062-nm distributed-feedback diode laser and a frequency-doubling element.
Akamatsu, Daisuke, Hong, Feng-Lei, Hosaka, Kazumoto, Inaba, Hajime, Kobayashi, Takumi, Okubo, Sho, Onae, Atsushi, Tanabe, Takehiko, Yasuda, Masami   +8 more
core   +2 more sources

The study of chiral adsorption systems using synchrotron- based structural and spectroscopic techniques: stereospecific adsorption of serine on Au-modified chiral Cu{531} surfaces [PDF]

, 2011
We apply modern synchrotron-based structural techniques to the study of serine adsorbed on the pure andAumodified intrinsically chiral Cu{531} surface.
Cornish, Alix, Eralp, Tugce, Held, Georg, Shavorskiy, Andrey   +3 more
core   +2 more sources

LIBRETTO-531: a phase III study of selpercatinib in multikinase inhibitor-naïve RET-mutant medullary thyroid cancer

Future Oncology, 2022
Selpercatinib is a first-in-class, highly selective and potent, central nervous system-active RET kinase inhibitor. In the phase I/II trial, selpercatinib demonstrated clinically meaningful antitumor activity with manageable toxicity in heavily pre ...
L. Wirth, M. Brose, R. Elisei, J. Capdevila, A. O. Hoff, Mimi I Hu, M. Tahara, B. Robinson, M. Gao, M. Xia, P. Maeda, E. Sherman   +11 more
semanticscholar   +1 more source

Study on the Effect of Ultraviolet Absorber UV-531 on the Performance of SBS-Modified Asphalt

Materials, 2022
Asphalt pavements at high altitudes are susceptible to aging and disease under prolonged action of UV light. To improve their anti-ultraviolet aging performance, UV-531/SBS-modified asphalts with UV-531 dopings of 0.4%, 0.7%, and 1.0% were prepared by ...
Li Liu, Leixin Liu, Z. Liu, Cheng-cheng Yang, Boyang Pan, Wenbo Li   +5 more
semanticscholar   +1 more source

BRCA1/2 pathogenic variants in triple-negative versus luminal-like breast cancers: genotype–phenotype correlation in a cohort of 531 patients

Therapeutic Advances in Medical Oncology, 2020
Background: Several available data suggest the association between specific molecular subtypes and BRCA1/2 mutational status. Previous investigations showed the association between BRCA1/2 pathogenic variants (PVs) in specific genomic regions and ...
L. Incorvaia, D. Fanale, M. Bono, V. Caló, A. Fiorino, C. Brando, L. Corsini, S. Cutaia, D. Cancelliere, A. Pivetti, C. Filorizzo, M. La Mantia, N. Barraco, S. Cusenza, G. Badalamenti, A. Russo, V. Bazan   +16 more
semanticscholar   +1 more source

Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

eLife, 2020
Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second leading cause of cancer-related death.
C. C. Au, J. Furness, K. Britt, Sofya Oshchepkova, Heta Ladumor, K. Soo, B. Callaghan, C. Gérard, G. Inghirami, V. Mittal, Yufeng Wang, Xin-Yun Huang, J. Spector, E. Andreopoulou, P. Zumbo, D. Betel, L. Dow, K. Brown   +17 more
semanticscholar   +1 more source

The Crisis of 2007-09: Nature, Causes, and Reactions [PDF]

, 2010
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Interntional Economic Law following peer review. The definitive publisher-authenticated version [Journal of International Economic Law 13(3):531-550 2010]
Lastra, RM, Wood, G
core   +1 more source

Exogenous and Endogenous Hydrogen Sulfide Protects Gastric Mucosa against the Formation and Time-Dependent Development of Ischemia/Reperfusion-Induced Acute Lesions Progressing into Deeper Ulcerations

Molecules, 2017
Hydrogen sulfide (H2S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST).
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Robert Pajdo, Grzegorz Ginter, Slawomir Kwiecien, Tomasz Brzozowski   +7 more
doaj   +1 more source