Results 21 to 30 of about 1,599,471 (325)

The BTK Inhibitor ARQ 531 Targets Ibrutinib-Resistant CLL and Richter Transformation.

Cancer Discovery, 2018
Targeted inhibition of Bruton tyrosine kinase (BTK) with the irreversible inhibitor ibrutinib has improved outcomes for patients with hematologic malignancies, including chronic lymphocytic leukemia (CLL).
S. Reiff, Rose Mantel, Lisa L. Smith, Joseph T. Greene, Elizabeth M Muhowski, Catherine A Fabian, V. Goettl, Minh H Tran, Bonnie K. Harrington, K. Rogers, F. Awan, K. Maddocks, L. Andritsos, A. Lehman, D. Sampath, R. Lapalombella, S. Eathiraj, G. Abbadessa, B. Schwartz, A. Johnson, J. Byrd, J. Woyach   +21 more
semanticscholar   +1 more source

Playful Probes for Design Interaction with Machine Learning: A Tool for Aircraft Condition-Based Maintenance Planning and Visualisation

Mathematics, 2022
Aircraft maintenance is a complex domain where designing new systems that include Machine Learning (ML) algorithms can become a challenge. In the context of designing a tool for Condition-Based Maintenance (CBM) in aircraft maintenance planning, this ...
Jorge Ribeiro, Pedro Andrade, Manuel Carvalho, Catarina Silva, Bernardete Ribeiro, Licínio Roque   +5 more
doaj   +1 more source

Final Results of Phase 1, Dose Escalation Study Evaluating ARQ 531 in Patients with Relapsed or Refractory B-Cell Lymphoid Malignancies

Blood, 2019
Introduction: Resistance to covalent BTK inhibitors such as ibrutinib and acalabrutinib is a common mechanism of resistance that portends a poor long-term clinical outcome.
J. Woyach, D. Stephens, I. Flinn, S. Bhat, R. Savage, F. Chai, S. Eathiraj, L. Granlund, L. Szuszkiewicz, B. Schwartz, J. Byrd   +10 more
semanticscholar   +1 more source

Chrystologiczny wymiar Iz 53,1–5

Studia Koszalińsko-Kołobrzeskie, 2017
The article attempts to capture Christology of Isaiah 53,1–5 (IV Songs of the Suffering Servant). Semiotics that the Pontifical Biblical Commission acknowledges as a tool of synchronic analysis was used in the study.
Małgorzata Piotrkowska-Dańkowska
doaj   +1 more source

Intestinal Alkaline Phosphatase Combined with Voluntary Physical Activity Alleviates Experimental Colitis in Obese Mice. Involvement of Oxidative Stress, Myokines, Adipokines and Proinflammatory Biomarkers

Antioxidants, 2021
Intestinal alkaline phosphatase (IAP) is an essential mucosal defense factor involved in the process of maintenance of gut homeostasis. We determined the effect of moderate exercise (voluntary wheel running) with or without treatment with IAP on the ...
Aleksandra Danielak, Dagmara Wojcik, Agnieszka Mazur-Bialy, Marcin Surmiak, Jan Bilski, Aneta Targosz, Marcin Magierowski, Anna Chmura, Malgorzata Strzalka, Gracjana Krzysiek-Maczka, Katarzyna Magierowska, Urszula Szczyrk, Sławomir Kwiecien, Agata Ptak-Belowska, Tomasz Brzozowski   +14 more
doaj   +1 more source

Unimodality of the freely selfdecomposable probability laws [PDF]

, 2015
We show that any freely selfdecomposable probability law is unimodal. This is the free probabilistic analog of Yamazato's result in [Ann. Probab.
Hasebe, Takahiro, Thorbjornsen, Steen
core   +2 more sources

Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.

Biochemistry, 2019
Aspirin and Celebrex are well-known time-dependent inhibitors of the Cyclooxygenases (COX). Molecular dynamics simulations suggest that Arg-513 and Leu-531 contribute to the structural mechanisms of COX inhibition.
Liang Dong, A. Anderson, M. Malkowski
semanticscholar   +1 more source

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage

Acta Pharmaceutica Sinica B, 2021
Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal integrity.
Dominik Bakalarz, Marcin Surmiak, Xiaoxiao Yang, Dagmara Wójcik, Edyta Korbut, Zbigniew Śliwowski, Grzegorz Ginter, Grzegorz Buszewicz, Tomasz Brzozowski, Jakub Cieszkowski, Urszula Głowacka, Katarzyna Magierowska, Zhixiang Pan, Binghe Wang, Marcin Magierowski   +14 more
doaj   +1 more source

Gaseous Mediators Nitric Oxide and Hydrogen Sulfide in the Mechanism of Gastrointestinal Integrity, Protection and Ulcer Healing

Molecules, 2015
Nitric oxide (NO) and hydrogen sulfide (H2S) are known as biological messengers; they play an important role in human organism and contribute to many physiological and pathophysiological processes.
Marcin Magierowski, Katarzyna Magierowska, Slawomir Kwiecien, Tomasz Brzozowski   +3 more
doaj   +1 more source

Audiologist’s Perspective in Auditory Rehabilitation: Implications for Ethical Conduct and Decision-Making in Portugal

Audiology Research, 2022
Ethical standards in audiology have been continuously improved and discussed, leading to the elaboration of specific regulatory guidelines for the profession.
Tatiana Marques, Margarida Silvestre, Bárbara Santa Rosa, António Miguéis   +3 more
doaj   +1 more source