Results 101 to 110 of about 17,983,967 (290)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
El Diálogo 5+5 y la iniciativa 5+5 defensa
Revista UNISCI, 2015 El Diálogo 5+5 es el foro activo de diálogo y cooperación más antiguo que existe entre los países europeos del Mediterráneo Occidental y los países del Magreb.
Javier Ignacio García
doaj
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Termination of Older Youth from Foster Care: A Protocol for Illinois [PDF]
, 2000 National data suggests that young people transitioning from wardship to adulthood experience the expectation of self sufficiency as too fast, unplanned and unexpected, making them feel "dumped" by the system, helpless to take control of their lives, and ...
Laurene Heybach, Stacey Platt
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Older Workers: Employment and Retirement Trends [PDF]
, 2004 As the members of the “baby boom” generation — people born between 1946 and 1964 — approach retirement, the demographic profile of the U.S. workforce will undergo a substantial shift: a large number of older workers will be joined by relatively few new ...
Purcell, Patrick
core +3 more sources
Dynamical Regional Downscaling Using the JRA-55 Reanalysis (DSJRA-55)
, 2016 DSJRA-55 (Kayaba et al. 2016) is a dynamical regional downscaling using the Japanese 55-year Reanalysis (JRA-55, Kobayashi et al. 2015) dataset for initial and boundary conditions.
Nobuyuki Kayaba +7 more
semanticscholar +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source