Results 81 to 90 of about 17,001,478 (281)
BEST AGERS ACTIVATION TOOLBOX – RESULTS OF THE RESEARCH
Research on Enterprise in Modern Economy Theory and Practice, 2012 In recent years, the fact to make more use of the knowledge and expertise of people aged 55+ years – called “Best Agers” – has been increasingly recognized. The usage of these skills is becoming more and more important. Due to this finding, the number
Frank Buettner +2 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Planck Intermediate Results II: Comparison of Sunyaev–Zeldovich measurements from Planck and from the Arcminute Microkelvin Imager for 11 galaxy clusters [PDF]
, 2012 A comparison is presented of Sunyaev–Zeldovich measurements for 11 galaxy clusters as obtained by Planck and by the ground-based interferom- eter, the Arcminute Microkelvin Imager.
1 +252 more
core +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Research on Enterprise in Modern Economy Theory and Practice, 2012 The first Baltic Forum for Youth Entrepreneurship “Q-Camp 2010” was held in Saint-Petersburg in October 6–9th 2010 being one of the steps of the international project Best Agers – using the knowledge and experience of professionals in their primes to ...
Philip Kazin
doaj
Вопросы вирусологииIntroduction. Adenovirus infection occurs globally in the form of sporadic cases and isolated outbreaks. Human adenovirus type 55 (HAdV-55), endemic in China and South Korea, causes acute respiratory viral infections (ARVI) of varying severity, both ...
Daniil A. Shein +11 more
doaj +1 more source
Magnetar crust electron capture for $$^{55}$$ 55 Co and $$^{56}$$ 56 Ni
European Physical Journal C: Particles and Fields, 2018 Based on the relativistic mean-field effective interaction principle and random phase approximation theory in superstrong magnetic fields (SMFs), we present an analysis of the influence of SMFs on the electron Fermi energy, nuclear blinding energy ...
Jing-Jing Liu, Dong-Mei Liu
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source