Results 101 to 110 of about 4,877,711 (265)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
(Table 2) Grain size analysis at DSDP Leg 55 Holes
, 1980 (Table 2) Grain size analysis at DSDP Leg 55 ...
Shipboard Scientific Party +1 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
08 Liebelei II (Josef Wagnes) [00:48] (KUG KD 55)
Text: Bruno Ertler Komposition: Josef Wagnes Interpret*innen: Birgit Stöckler (Sopran), Maria Lerchenberger (Tenor), Petar Karagenov (Klavier), Christoph Hammer (Geige), Tom Sol (Sprecher), Harald Haslmayr (Moderator) Album: Bruno Ertler "Ewigkeiten" und
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
15 Der Spielmann (Herbert Zagler) [02:03] (KUG KD 55)
Text: Bruno Ertler Komposition: Herbert Zagler Interpret*innen: Birgit Stöckler (Sopran), Maria Lerchenberger (Tenor), Petar Karagenov (Klavier), Christoph Hammer (Geige), Tom Sol (Sprecher), Harald Haslmayr (Moderator) Album: Bruno Ertler "Ewigkeiten ...
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
21Abschied (Leopold Welleba) [02:38] (KUG KD 55)
Text: Bruno Ertler Komposition: Leopold Welleba Interpret*innen: Birgit Stöckler (Sopran), Maria Lerchenberger (Tenor), Petar Karagenov (Klavier), Christoph Hammer (Geige), Tom Sol (Sprecher), Harald Haslmayr (Moderator) Album: Bruno Ertler "Ewigkeiten ...
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