Results 171 to 180 of about 17,983,967 (290)

Real-World Performance of HPV DNA-Based Screening in Health Resource-Limited Areas of China: A Multicenter Implementation Study. [PDF]

Cancer Epidemiol Biomarkers Prev
Jia X, Da X, Shi J, Chen M, Duan R, Li Z, Feng R, Yang C, Ding H, Qiao Y.   +9 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

55. ‘O MUNACIELLO

Babel: Littératures Plurielles, 2017
Camillo De Felice
doaj   +1 more source

Severity and distribution of coronary artery disease in lebanese patients undergoing coronary angiography: Impact of gender and age on angiographic characteristics, a cross-sectional study. [PDF]

Medicine (Baltimore)
Al Chaar S, Al Hajj A, Nakad P, Sarraf A, Halby J, Fakhry B, Zahwi A, Feghali G, Chahine MN.   +8 more
europepmc   +1 more source

Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

Cell, 1999
M. McDermott, I. Aksentijevich, J. Galon, E. McDermott, B. Ogunkolade, M. Centola, E. Mansfield, M. Gadina, L. Karenko, T. Pettersson, J. McCarthy, D. M. Frucht, M. Aringer, Yelizaveta Torosyan, A. Teppo, Meredith Wilson, H. Karaarslan, Y. Wan, I. Todd, G. Wood, R. Schlimgen, T. R. Kumarajeewa, S. M. Cooper, J. Vella, Christopher I. Amos, J. Mulley, K. Quane, M. G. Molloy, A. Ranki, R. Powell, G. Hitman, John J. O'Shea, D. L. Kastner   +32 more
semanticscholar   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients. [PDF]

ERJ Open Res
Porcel JM, Porcel L, Palma R, Bielsa S.
europepmc   +1 more source

An International Multi-Institutional Validation of Age 55 Years as a Cutoff for Risk Stratification in the AJCC/UICC Staging System for Well-Differentiated Thyroid Cancer

Thyroid, 2016
I. Nixon, Laura Y. Wang, Jocelyn Migliacci, Antoine Eskander, M. Campbell, Ahmad M Aniss, Lilah F. Morris, F. Vaisman, R. Corbo, D. Momesso, M. Vaisman, A. Carvalho, D. Learoyd, W. Leslie, R. Nason, D. Kuk, V. Wreesmann, L. Morris, Frank L. Palmer, I. Ganly, S. Patel, Bhuvanesh Singh, R. Tuttle, A. Shaha, M. Gönen, K. Pathak, W. Shen, M. Sywak, L. Kowalski, J. Freeman, N. Perrier, Jatin P. Shah   +31 more
semanticscholar   +1 more source