Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Línea de investigación Conocimiento Profesional del Profesor de Ciencias
Bio-grafía, 2009 Hacemos la presentación de las características y desarrollos de la Línea de Investigación Conocimiento Profesional del Profesor de Ciencias, de la Universidad Pedagógica Nacional (Colombia), la cual viene realizando actividades de docencia, investigación
Édgar Orlay Valbuena Ussa (Página 55-78)
doaj
Electrical engineering & Electromechanics, 2020 Wind turbines with permanent magnet synchronous generator (PMSG) are widely used as sources of energy connected to a grid. The studied system is composed of a wind turbine based on PMSG, a bridge rectifier, a boost converter, and a controlled inverter to
I. Boukhechem +3 more
doaj +1 more source
PENERAPAN MODEL PROBLEM BASED LEARANING DENGAN TEKNIK E–LEARNING TERHADAP HASIL BELAJAR PESERTA DIDIK MATA PELAJARAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN ( Penelitian Tindakan Kelas ( PTK)materi pokok “ Pancasila Sebagai Ideologi Dan Dasar Negara” Kelas VIII –H di SMP Pasundan 1 Bandung ) [PDF]
, 2016 Kata kunci (keyword) : Penerapan, model pembelajaran problem based learning , teknik E - Learning , terhadap , hasil belajar, peserta didik..
Rana Ahmad Juliana, 1250100 55
core +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
5,5′-Thiobis(3-bromoisothiazole-4-carbonitrile)
MolbankThe reaction of sodium 2,2-dicyanoethene-1,1-bis(thiolate) with bromine (2 equiv.) in CCl4 gave 3,5-dibromoisothiazole-3-carbonitrile and 5,5′-thiobis(3-bromoisothiazole-4-carbonitrile) in 7% and 18% yields, respectively.
Andreas S. Kalogirou +1 more
doaj +1 more source
The Challenge of Theodicy and the Divine Access to the Universe [PDF]
, 2009 Any new attempt to cope with the problem of theodicy is forced to reinterpret and remodify the classic set of divine attributes. Classical monotheism, at least in the Christian or Islamic tradition, emphasizes the concept of God as a personal, almighty ...
Schärtl, Thomas
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source