Results 91 to 100 of about 1,449,708 (342)

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai   +12 more
wiley   +1 more source

Reverse method for labeling the information from semi-structured web pages

open access: yes, 2009
We propose a new technique to infer the structure and extract the tokens of data from the semi-structured web sources which are generated using a consistent template or layout with some implicit regularities.
Akbar, Z., Handoko, L. T.
core   +1 more source

Flatness optimization of micro-injection moulded parts: The case of a PMMA microfluidic component [PDF]

open access: yes, 2011
Micro-injection moulding (µ-IM) has attracted a lot of interest because of its potential for the production of low-cost, miniaturized parts in high-volume.
Alcock, Jeffrey R.   +5 more
core   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

Real Hypersurfaces of Type A in Complex Two-Plane Grassmannians Related to The Reeb Vector Field

open access: yes, 2015
Y. J. Suh and H. Lee (Bull. Korean. Math. Soc. 47, 551-561 (2010)) characterized real hypersurfaces $M$ of type $B$ by the invariance of vector bundle $JTM^\perp$ under the shape operator and the orthogonality of $JTM^\perp$ and $\mathcal {J}TM^\perp ...
Lee, Ruenn-Huah, Loo, Tee-How
core   +1 more source

A Question of Coherence [PDF]

open access: yes, 2016
open1noElectromagnetic waves were first postulated by James Clerk Maxwell (1831-1879) in 1865. To demonstrate their existence 22 years later, Heinrich Hertz (1857-1894) had to design new instrumentation that he used to carry out an experiment than had ...
Guarnieri, Massimo
core   +1 more source

Reconfigurable Acoustofluidic Microvortices for Selective Microcargo Delivery

open access: yesAdvanced Science, EarlyView.
This work introduces a frequency‐encoded, reconfigurable acoustofluidic system that overcomes the low throughput and poor selectivity of conventional micro‐delivery methods. By exploiting discrete microbubble resonances to program adaptive microvortex modes, the platform enables real‐time switching and selective guidance of microscale payloads through ...
Lei Wang   +6 more
wiley   +1 more source

Re‐evaluation of silicon dioxide (E 551) as a food additive in foods for infants below 16 weeks of age and follow‐up of its re‐evaluation as a food additive for uses in foods for all population groups

open access: yesEFSA Journal
The present opinion is the follow‐up of the conclusions and recommendations of the Scientific Opinion on the re‐evaluation of silicon dioxide (E 551) as a food additive relevant to the safety assessment for all age groups.
EFSA Panel on Food Additives and Flavourings (FAF)   +53 more
doaj   +1 more source

Deformation and strengthening behavior of Al-Cu-based alloys at ambient and elevated temperatures

open access: yesAcademia Materials Science
Aluminum alloys typically exhibit low to intermediate strength. Heat treatment may improve their strength through precipitation hardening. Al-Cu-based alloys have shown appropriate mechanical properties based on their specific strengthening ...
Mehran Shahhosseininia   +1 more
doaj   +1 more source

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