#5699 IS GFR DECLINE INDUCED BY SGLT-2 INHIBITOR OF CLINICAL IMPORTANCE?
Nephrology Dialysis Transplantation, 2023 Abstract Background and Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are associated with better cardiovascular outcome and with nephroprotection independent of diabetes status. However, the use of SGLT2i often cause an initial decline in estimated glomerular filtration rate (eGFR).
Agnes Bosch +2 more
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The English past tense as a definite description
Glossa, 2023 There are two major groups of analyses in the literature on the English past tense; existential semantics with domain restriction, and the pronominal (i.e. anaphoric) analysis. In this paper, I discuss a group of data difficult for both of these analyses:
Ruoying Zhao
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Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey [PDF]
Molecular OncologyThis study aimed to evaluate KRAS and NRAS mutations over an eight‐year period to provide a comprehensive understanding of the genetic landscape of metastatic colorectal cancer (mCRC) in Turkish patients.
Gozde Kavgaci +6 more
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Cancer Research, 2017 Abstract The purpose of this study was to explore the potential of urine DNA biomarkers for the early detection of primary hepatocellular carcinoma (HCC). HCC is an aggressive disease with a 5-year survival rate of 26% in early-stage cancers, and a mere 2% in later stages. The most commonly used screening biomarker for HCC is serum alpha-
Surbhi Jain +7 more
openaire +2 more sources
Transcriptome-wide association study identifies genes associated with bladder cancer risk [PDF]
Scientific ReportsGenome-wide association studies (GWAS) have detected several susceptibility variants for urinary bladder cancer, but how gene regulation affects disease development remains unclear.
Siting Li +3 more
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Advanced SciencePancreatic cancer is one of the most lethal malignancies. Genome‐wide association studies (GWAS) identify multiple susceptibility loci, but most map to noncoding regions, leaving variant‐to‐gene links unresolved.
Xiaoyang Wang +14 more
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Clinical effectiveness of procalcitonin- or C-reactive protein-guided antibiotic discontinuation protocols for adult patients who are critically ill with sepsis: a rapid systematic review and meta-analysis. [PDF]
AnaesthesiaSummary Introduction Antibiotics are a first‐line treatment for sepsis, with guidelines recommending a 7‐ to 10‐day course. Prolonged antibiotic use carries significant risks, prompting growing interest in using inflammatory biomarkers, such as procalcitonin or C‐reactive protein, to guide clinical decision‐making on the duration of antibiotic therapy ...
Rafiq S +6 more
europepmc +2 more sources
Comprehensive Protocol for Handling Human Small Airway Epithelial Cells (HSAECs) to Establish Air–Liquid Interface (ALI) Cultures With TEER-Based Barrier Integrity Assessment [PDF]
Bio-ProtocolUnderstanding epithelial barrier function is essential for studying both its normal physiology and its role in disease, yet choosing an appropriate experimental model remains challenging. Animal models are commonly used but often suffer from interspecies
Dominika Jakubczyk +5 more
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Four Centuries of Clinical Chemistry. Louis Rosenfeld. Amsterdam, The Netherlands: Gordon and Breach Science Publishers, 1999, 592 pp., $149.00. ISBN 90-5699-645-2. [PDF]
Clinical Chemistry, 2000 This 500-plus page book represents an enormous effort and describes in great detail the development of many areas of clinical chemistry. The author has a passion for his subject and a great understanding of the principles of chemistry and their application to clinical issues.
Amadeo J Pesce
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